The synthesis of [phenyl-2H5]gluconasturtiin and its metabolites for metabolic studies

被引：13
|
作者：
Morrison, JJ [1 ]
Botting, NP [1 ]
机构：
[1] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2005年 / 48卷 / 12期
关键词：
glucosinolates; isothiocyanates; gluconasturtiin; cancer prevention;
D O I：
10.1002/jlcr.1004
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of a deuterium labelled glucosinolate, [H-2(5)] gluconasturtiin, is described starting from [H-2(5)]bromobenzene. The potential metabolites of the glucosinolate, namely the [pheny-H-2(5)]phenethyl isothiocyanate, nitrile, thiocyanate, amine and the mercapturic acid conjugate of phenethyl isothiocyanate are also described. This series of compounds has been prepared for use in feeding studies to examine the mammalian metabolism of gluconasturtiin and search for new biomarkers of exposure. Copyright (c) 2005 John Wiley & Sons, Ltd.
引用
收藏
页码：897 / 907
页数：11
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