Visible-Light-Induced C-F and C-N Bond Cleavage for the Synthesis of gem-Difluoroalkenes

被引：13
|
作者：
Wang, Bin [1 ]
Wang, Cui-Tian [1 ]
Li, Xue-Song [1 ]
Liu, Xue-Yuan [1 ]
Liang, Yong-Min [1 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源：
ORGANIC LETTERS | 2022年 / 24卷 / 36期
基金：
中国国家自然科学基金;
关键词：
TRIFLUOROMETHYL ALKENES; DEAMINATIVE ALKYLATION; ACTIVATION;
D O I：
10.1021/acs.orglett.2c02528
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we describe a novel and efficient photoredox catalytic radical addition/defluoroalkylation coupling reaction between primary amines and trifluoromethyl-substituted alkenes. A series of gem-difluoroalkenes were synthesized via C-N bond cleavage of alpha-3 degrees , alpha-2 degrees, and alpha-1 degrees amines under visible light irradiation. This reaction is characterized by a broad substrate scope and good functional group tolerance.
引用
收藏
页码：6566 / 6570
页数：5
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