Organocatalytic asymmetric synthesis of 2,4-disubstituted imidazolidines via domino addition-aza-Michael reaction

被引：28
|
作者：
Mukhopadhyay, Soumendranath [1 ]
Pan, Subhas Chandra [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, Gauhati 781039, India
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 08期
关键词：
AZOMETHINE YLIDES; 1,3-DIPOLAR CYCLOADDITIONS; CONJUGATE ADDITION; ALPHA; BETA-UNSATURATED ENONES; BIFUNCTIONAL ORGANOCATALYSTS; ENANTIOSELECTIVE SYNTHESIS; CONSTRUCTION; DERIVATIVES; IMINES; PYRROLIDINES;
D O I：
10.1039/c7cc08338f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The first highly diastereo-and enantioselective synthesis of 2,4-disubstituted imidazolidines has been developed via a formal [3+2] cyclization reaction. Bidentate aminomethyl enones and N-tosyl imines were used as the reaction partners in the reaction. Bifunctional squaramide catalysts were found to be efficient for this reaction and few transformations of the products have been demonstrated.
引用
收藏
页码：964 / 967
页数：4
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