Application of accelerator mass spectrometry (AMS) in early drug development. Part 1. Background and procedures

被引：0

作者：

Lipner, Grzegorz ^{[1
]}

Grynkiewicz, Grzegorz ^{[1
]}

机构：

[1] Inst Farmaceuty, Zakladzie Chem, PL-01793 Warsaw, Poland

来源：

PRZEMYSL CHEMICZNY | 2012年 / 91卷 / 03期

关键词：

IN-VIVO; PHARMACOKINETICS; EXPERIENCE; FUTURE; VOLUNTEERS; NUCLEAR; MEIQX; MICE; DNA;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A review, with 40 refs., and fundamentals of combined applications of linear accelerator and high resolution mass spectrometer for detection of org. compds. containing suitable C-14 labels in femtomol concns. for studying pharmacokinetic parameters and metabolic fate of drugs from single sub-pharmacolog. dose.

引用

页码：314 / 318

页数：5

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