Design of NiCo2O4 nanoflowers decorated sulfurbridged covalent triazine frameworks nanocomposites for electrochemical simultaneous detection of acetaminophen and 4-aminophenol

Owing to the high toxicity of acetaminophen (ACOP) and 4-aminophenol (4-AP) when they are overused, the simultaneous determination of ACOP and 4-AP is crucial. In this present paper, an electrochemical sensor based on the nanocomposite of sulfurbridged covalent triazine frameworks (S-CTFs) and in situ formed nickel cobaltite (NiCo2O4) nanoflowers on S-CTFs, denoted as S-CTEs@NiCo2O4, was fabricated for the first time for sensitive detection of ACOP and 4-AP. S-CTEs@NiCo2O4 modified electrode exhibited the outstanding synergetic effects of S-CTFs (prominent enrichment ability and large surface area) and NiCo2O4 (excellent electrocatalytic activity). The developed electrode had the advantages of high reproducibility, repeatability, anti-interference and stability, and it exhibited a wide linear concentration range (2 similar to 360 mu M) and a low limit of detection (0.18 mu M and 0.35 mu M) for ACOP and 4-AP, respectively. In addition, the designed electrochemical sensor was evaluated towards the detecting ACOP and 4-AP in real samples with satisfactory recovery, illustrating that electrode has a broad prospect in the clinical application.