Synthesis of indolines via a domino Cu-catalyzed amidation/cyclization reaction

被引：95
|
作者：
Minatti, Ana [1 ]
Buchwald, Stephen L. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 13期
关键词：
D O I：
10.1021/ol8008792
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient one-pot procedure for the synthesis of indolines and their homologues based on a domino Cu-catalyzed amidation/nucleophilic substitution reaction has been developed. Substituted 2-iodophenethyl mesylates and related compounds afforded the corresponding products in excellent yields. No erosion of optical purity was observed when transforming enantiomerically pure mesylates under the reaction conditions.
引用
收藏
页码：2721 / 2724
页数：4
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