Antiinflammatory activity of 4,5-disubstituted-3-methyl-1,3a, 4,5-tetrahydropyrazolo [3,4-c] pyrazoles

被引：0
|
作者：
Bhaskar, V. H. [1 ]
Balakrishnan, B. R. [1 ]
Sangameswaran, B. [1 ]
机构：
[1] Vinayaka Missions Univ, Fac Pharm, Salem 636008, Tamil Nadu, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2007年 / 17卷 / 02期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ethyl acetoacetate (I) was stirred with hydrazine hydrate in ethanol to get 5-methyl-2,4-dihydro-3H-pyrazol-3-one (II). This was refluxed with different aryl aldehydes in gl acetic acid in presence of fused sodium acetate to get corresponding (4Z)-4-arylidene-5-methyl-2,4-dihydro-3H-pyrazol-3-ones (IIIa-f). These III were treated with 2,4-dinitrophenylhydrazine to get a series of 4,5-disubtituted 3-methyl-1, 3a,4,5-tetrahydropyrazolo [3,4-c] pyrazoles. The structures of the compounds have been established based on their analytical and spectral data. All the compounds have been screened for their antiinflammatory activity. Compound IVb and IVd exhibited good antiinflammatory activity.
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页码：131 / 134
页数：4
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