Serum glial cell derived neurotrophic factor (GDNF) as a predictor of response to HD-tDCS in bipolar affective disorder

被引：1

作者：

Veenakumari, M. ^{[1
]}

Goyal, Nishant ^{[1
]}

Kumar, Mahesh ^{[1
]}

Kshitiz, K. K. ^{[1
]}

Kumar, Pramod ^{[2
]}

机构：

[1] Cent Inst Psychiat, Ranchi 834006, Jharkhand, India

[2] Rajendra Inst Med Sci, Ranchi 834009, Jharkhand, India

来源：

ASIAN JOURNAL OF PSYCHIATRY | 2022年 / 68卷

关键词：

GDNF; HD-tDCS; Bipolar disorder; PREFRONTAL CORTEX; STIMULATION; EXPRESSION; MANIA;

D O I：

10.1016/j.ajp.2021.102965

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Serum glial cell line derived neurotrophic factor (GDNF) homeostasis within brain circuits represent target for focal neuromodulation techniques such as high-definition transcranial direct current stimulation (HD-tDCS). In current trial 37 inpatients with bipolar disorder (BD) received active (n = 18) or sham (n = 19) anodal HD-tDCS over right dorsolateral prefrontal cortex (DLPFC). Outcome measures evaluated by YMRS (p = 0.001, effect size=0.946), BPRS (p = 0.015, effect size=0.220) scales and serum GDNF (p = 0.003, effect size = 0.287) at baseline, before and after receiving HD-tDCS revealed significant improvement (active>sham) with modest ef-fect size. However, the study findings are limited due to small sample size and shorter duration of follow-up.

引用

页数：4

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