Single Nucleotide Polymorphisms from CSF2, FLT1, TFPI and TLR9 Genes Are Associated with Prelabor Rupture of Membranes

被引：6
|
作者：
Wujcicka, Wioletta Izabela [1 ]
Kacerovsky, Marian [2 ,3 ]
Krekora, Michal [4 ,5 ]
Kaczmarek, Piotr [6 ]
Grzesiak, Mariusz [5 ,7 ]
机构：
[1] Polish Mothers Mem Hosp Res Inst, Sci Lab Ctr Med Lab Diagnost & Screening, 281-289 Rzgowska St, PL-93338 Lodz, Poland
[2] Charles Univ Prague, Univ Hosp Hradec Kralove, Fac Med Hradec Kralove, Dept Obstet & Gynecol, Simkova 870, Hradec Kralove 50003, Czech Republic
[3] Univ Hosp Hradec Kralove, Biomed Res Ctr, Hradec Kralove 50003, Czech Republic
[4] Polish Mothers Mem Hosp, Dept Obstet & Gynecol, Res Inst, PL-93338 Lodz, Poland
[5] Med Univ Lodz, Dept Gynecol & Obstet, 281-289 Rzgowska St, PL-93338 Lodz, Poland
[6] Polish Mothers Mem Hosp, Lab Prenatal Fetal & Maternal Diagnost, Res Inst, PL-93338 Lodz, Poland
[7] Polish Mothers Mem Hosp, Dept Perinatol Obstet & Gynecol, Res Inst, PL-93338 Lodz, Poland
来源：
GENES | 2021年 / 12卷 / 11期
关键词：
prelabor rupture of membranes (PROM); pPROM; tPROM; hemostasis; angiogenesis; pregnancy; genotyping; single nucleotide polymorphism (SNP); restriction fragment length polymorphism (RFLP); PRETERM PREMATURE RUPTURE; MEAN PLATELET VOLUME; TOLL-LIKE RECEPTORS; TISSUE FACTOR; AMNIOTIC-FLUID; PROMOTES ANGIOGENESIS; PERINATAL OUTCOMES; MYCOPLASMA-HOMINIS; ENDOTHELIAL-CELLS; FETAL MEMBRANES;
D O I：
10.3390/genes12111725
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A prelabor rupture of membranes (PROM) and its subtypes, preterm PROM (pPROM) and term PROM (tPROM), are associated with disturbances in the hemostatic system and angiogenesis. This study was designed to demonstrate the role of single nucleotide polymorphisms (SNPs), localized in CSF2 (rs25881), FLT1 (rs722503), TFPI (C-399T) and TLR9 (rs352140) genes, in PROM. A population of 360 women with singleton pregnancy consisted of 180 PROM cases and 180 healthy controls. A single-SNP analysis showed a similar distribution of genotypes in the studied polymorphisms between the PROM or the pPROM women and the healthy controls. Double-SNP TT variants for CSF2 and FLT1 polymorphisms, CC variants for TLR9 and TFPI SNPs, TTC for CSF2, FLT1 and TLR9 polymorphisms, TTT for FLT1, TLR9 and TFPI SNPs and CCCC and TTTC complex variants for all tested SNPs correlated with an increased risk of PROM after adjusting for APTT, PLT parameters and/or pregnancy disorders. The TCT variants for the CSF2, FLT1 and TLR9 SNPs and the CCTC for the CSF2, FLT1, TLR9 and TFPI polymorphisms correlated with a reduced risk of PROM when corrected by PLT and APTT, respectively. We concluded that the polymorphisms of genes, involved in hemostasis and angiogenesis, contributed to PROM.
引用
收藏
页数：23
相关论文
共 25 条
  • [11] Single-Nucleotide Polymorphisms in NOD1, RIPK2, MICB, PLCE1, TNF, and IKBKE Genes Associated with Symptomatic Dengue in Children from Colombia
    Magnolia Useche, Yerly
    Ribeiro-Alves, Marcelo
    Restrepo, Berta-Nelly
    Martha Salgado, Doris
    Fernando Narvaez, Carlos
    Campo, Omer
    Avendano, Efren
    Martinez, Catalina
    Chacon-Duque, Juan Camilo
    Bedoya, Gabriel
    VIRAL IMMUNOLOGY, 2018, 31 (09) : 613 - 623
  • [12] Role of polymorphisms of toll-like receptor (TLR) 4, TLR9, toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children
    Esposito, Susanna
    Molteni, Claudio Giuseppe
    Zampiero, Alberto
    Baggi, Elena
    Lavizzari, Anna
    Semino, Margherita
    Daleno, Cristina
    Groppo, Michela
    Scala, Alessia
    Terranova, Leonardo
    Miozzo, Monica
    Pelucchi, Claudio
    Principi, Nicola
    MALARIA JOURNAL, 2012, 11
  • [13] Role of polymorphisms of toll-like receptor (TLR) 4, TLR9, toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children
    Susanna Esposito
    Claudio Giuseppe Molteni
    Alberto Zampiero
    Elena Baggi
    Anna Lavizzari
    Margherita Semino
    Cristina Daleno
    Michela Groppo
    Alessia Scala
    Leonardo Terranova
    Monica Miozzo
    Claudio Pelucchi
    Nicola Principi
    Malaria Journal, 11
  • [14] Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11 and PPARG2 in type 1 diabetes
    Eftychi, C
    Howson, JMM
    Barratt, BJ
    Vella, A
    Payne, F
    Smyth, DJ
    Twells, RCJ
    Walker, NM
    Rance, HE
    Tuomilehto-Wolf, E
    Tuomilehto, J
    Undlien, DE
    Ronningen, KS
    Guja, C
    Ionescu-Tîrgoviste, C
    Savage, DA
    Todd, JA
    DIABETES, 2004, 53 (03) : 870 - 873
  • [15] Single Nucleotide Polymorphisms in the Arginase 1 and 2 Genes Are Differentially Associated with Circulating L-Arginine Concentration in Unsupplemented and L-Arginine-Supplemented Adults
    Hannemann, Juliane
    Rendant-Gantzberg, Leonard
    Zummack, Julia
    Hillig, Jonas
    Eilermann, Ina
    Boger, Rainer
    JOURNAL OF NUTRITION, 2021, 151 (04): : 763 - 771
  • [16] Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia
    Sakowicz, Agata
    Lisowska, Michalina
    Biesiada, Lidia
    Rybak-Krzyszkowska, Magda
    Gach, Agnieszka
    Sakowicz, Bartosz
    Grzesiak, Mariusz
    Huras, Hubert
    Pietrucha, Tadeusz
    DISEASE MARKERS, 2018, 2018
  • [17] Can Previous Associations of Single Nucleotide Polymorphisms in the TLR2, NOD1, CXCR5, and IL10 Genes in the Susceptibility to and Severity of Chlamydia trachomatis Infections Be Confirmed?
    Jukema, Jelmer B.
    Hoenderboom, Bernice M.
    van Benthem, Birgit H. B.
    Van der Sande, Marianne A. B.
    de Vries, Henry J. C.
    Hoebe, Christian J. P. A.
    Dukers-Muijrers, Nicole H. T. M.
    Bax, Caroline J.
    Morre, Servaas A.
    Ouburg, Sander
    PATHOGENS, 2021, 10 (01): : 1 - 16
  • [18] Polymorphisms in the Inflammatory Pathway Genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG Are Associated with Susceptibility of Inflammatory Bowel Disease in a Danish Cohort
    Bank, Steffen
    Andersen, Paal Skytt
    Burisch, Johan
    Pedersen, Natalia
    Roug, Stine
    Galsgaard, Julie
    Turino, Stine Ydegaard
    Brodersen, Jacob Broder
    Rashid, Shaista
    Rasmussen, Britt Kaiser
    Avlund, Sara
    Olesen, Thomas Bastholm
    Hoffmann, Hans Jurgen
    Thomsen, Marianne Kragh
    Thomsen, Vibeke Ostergaard
    Frydenberg, Morten
    Nexo, Bjorn Andersen
    Sode, Jacob
    Vogel, Ulla
    Andersen, Vibeke
    PLOS ONE, 2014, 9 (06):
  • [19] Functional Single-Nucleotide Polymorphisms in the MBL2 and TLR3 Genes Influence Disease Severity in Influenza A (H1N1)pdm09 Virus-Infected Patients from Maharashtra, India
    Choudhary, Manohar Lal
    Chaudhary, Urmila
    Salve, Malvika
    Shinde, Pooja
    Padbidri, Vikram
    Sangle, Shashikala A.
    Salvi, Sonali
    Bavdekar, Ashish R.
    D'costa, Pradeep
    Alagarasu, Kalichamy
    VIRAL IMMUNOLOGY, 2022, 35 (04) : 303 - 309
  • [20] Correlations between single nucleotide polymorphisms in bovine CD209 , SLC11A1 , SP110 and TLR2 genes and estimated breeding values for several traits in Spanish Holstein cattle
    Canive, Maria
    Casais, Rosa
    Jimenez, Jose A.
    Blanco-Vazquez, Cristina
    Amado, Javier
    Garrido, Joseba M.
    Juste, Ramon A.
    Alonso-Hearn, Marta
    HELIYON, 2020, 6 (06)
123