Molecular and cellular biology of pre-malignancy in the gastrointestinal tract

被引：14

作者：

Jass, JR ^{[1
]}

Talbot, IC ^{[1
]}

机构：

[1] Univ Queensland, Mayne Med Sch, Dept Pathol, Herston, Qld 4006, Australia

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2001年 / 15卷 / 02期

关键词：

genetic instability; methylation; oncogenes; tumour suppressor genes; adenoma; dysplasia; polyposis; colorectum;

D O I：

10.1053/bega.2000.0168

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Important pathogenic alterations within established cancers are acquired during the premalignant stage. These genetic alterations can be grouped into specific neoplastic pathways that differ within and between anatomical sites. By understanding the mechanisms that determine the initiation and progression of each pathway, it will be possible to develop novel approaches to the diagnosis, prevention and treatment of cancer. This chapter outlines the principles underlying the molecular characterization of pre-malignant lesions, taking colorectal neoplasia as the main model.

引用

页码：175 / 189

页数：15

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