Life expectancy in British Marfan syndrome populations

被引：0

作者：

Gray, JR ^{[1
]}

Bridges, AB

West, RR

McLeish, L

Stuart, AG

Dean, JCS

Porteous, MEM

Boxer, M

Davies, SJ

机构：

[1] Univ Wales Hosp, Inst Med Genet, Cardiff CF4 4XW, S Glam, Wales

[2] Stirling Royal Infirm, NHS Trust, Stirling FK8 2AU, Scotland

[3] Univ Wales Coll Med, Cardiff CF4 4XN, S Glam, Wales

[4] Univ Dundee, Ninewells Hosp & Med Sch, Dept Pathol, Dundee DD1 9SY, Scotland

[5] Univ Wales Hosp, Dept Cardiol, Cardiff CF4 4XW, S Glam, Wales

[6] Aberdeen Royal Infirm, Aberdeen Royal Hosp, NHS Trust, Dept Med Genet, Aberdeen, Scotland

[7] Western Gen Hosp, Dept Med Genet, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

CLINICAL GENETICS | 1998年 / 54卷 / 02期

关键词：

life expectancy; Marfan syndrome; survival;

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A total of 206 patients with Marfan syndrome were ascertained throughout genetic clinics in Wales and Scotland during the period 1970-1990. There were 45 deaths representing 22% of the cohort. Mean age at death was 45.3 +/- 16.5 years. 50% median cumulative survival in the total cohort (n = 206) was 53 years for males and 72 years for females. Multivariate analysis confirmed severity as the best independent indicator of survival. These findings and survival curves will assist in the counselling of British families and individuals with Marfan syndrome.

引用

页码：124 / 128

页数：5

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