Synthesis and transdermal penetration of NSAID glycoside esters

被引：33
|
作者：
Henk, SA
Breytenbach, JC [1 ]
Hadgraft, J
du Plessis, J
机构：
[1] NW Univ, Sch Pharm, ZA-2520 Potchefstroom, South Africa
[2] Univ London, Sch Pharm, London WC1N 1AX, England
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2005年 / 301卷 / 1-2期
基金：
新加坡国家研究基金会;
关键词：
flurbiprofen; ibuprofen; ketoprofen; naproxen; glycoside; transdermal penetration;
D O I：
10.1016/j.ijpharm.2005.05.030
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The glucoside and mannoside derivatives of the NSAIDs flurbiprofen, ibuprofen, ketoprofen and naproxen were synthesised and their penetration through human skin was determined. Experimental transdermal flux data showed that the parent NSAIDs penetrated human skin to a much higher extent than the glycosides. (C) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：71 / 79
页数：9
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