Synthesis and transdermal penetration of NSAID glycoside esters

被引：33
|
作者：
Henk, SA
Breytenbach, JC [1 ]
Hadgraft, J
du Plessis, J
机构：
[1] NW Univ, Sch Pharm, ZA-2520 Potchefstroom, South Africa
[2] Univ London, Sch Pharm, London WC1N 1AX, England
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2005年 / 301卷 / 1-2期
基金：
新加坡国家研究基金会;
关键词：
flurbiprofen; ibuprofen; ketoprofen; naproxen; glycoside; transdermal penetration;
D O I：
10.1016/j.ijpharm.2005.05.030
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The glucoside and mannoside derivatives of the NSAIDs flurbiprofen, ibuprofen, ketoprofen and naproxen were synthesised and their penetration through human skin was determined. Experimental transdermal flux data showed that the parent NSAIDs penetrated human skin to a much higher extent than the glycosides. (C) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：71 / 79
页数：9
相关论文
共 50 条
  • [1] Synthesis and Transdermal Penetration of Stavudine-5′-Esters
    Holmes, Estee-Marie
    Breytenbach, Jaco C.
    Gerber, Minja
    du Plessis, Jeanetta
    MEDICINAL CHEMISTRY, 2010, 6 (05) : 271 - 276
  • [2] Synthesis and Evaluation of Transdermal Permeation, Pharmacological Activity of Bornyl NSAID Esters
    Lin, Jiufeng
    Ni, Kefeng
    Zhang, Yang
    Wei, Dongzhi
    Ren, Yuhong
    LETTERS IN DRUG DESIGN & DISCOVERY, 2015, 12 (01) : 72 - 77
  • [3] Effects of cholesterol and its esters on transdermal penetration of phenazepam
    I. A. Kravchenko
    N. S. Novikova
    V. B. Larionov
    E. S. Pavlovskaya
    Pharmaceutical Chemistry Journal, 2009, 43 : 1 - 3
  • [4] EFFECTS OF CHOLESTEROL AND ITS ESTERS ON TRANSDERMAL PENETRATION OF PHENAZEPAM
    Kravchenko, I. A.
    Novikova, N. S.
    Larionov, V. B.
    Pavlovskaya, E. S.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2009, 43 (01) : 1 - 3
  • [5] Synthesis of Esters of the Monoterpene Glycoside Paeoniflorin
    Baltina, L. A., Jr.
    Kondratenko, R. M.
    Spirikhin, L. V.
    Baltina, L. A.
    CHEMISTRY OF NATURAL COMPOUNDS, 2016, 52 (02) : 347 - 349
  • [6] Synthesis and in vitro transdermal penetration enhancing activity of lactam N-acetic acid esters
    Michniak, BB
    Player, MR
    Sowell, JW
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1996, 85 (02) : 150 - 154
  • [7] Synthesis of Esters of the Monoterpene Glycoside Paeoniflorin
    L. A. Baltina
    R. M. Kondratenko
    L. V. Spirikhin
    L. A. Baltina
    Chemistry of Natural Compounds, 2016, 52 : 347 - 349
  • [8] Synthesis and transdermal penetration-enhancing activity of carbonic and carbamic acid esters -: Comparison with transkarbam 12
    Klimentová, J
    Hrabálek, A
    Vávrová, K
    Holas, T
    Kroutil, A
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (07) : 1981 - 1984
  • [9] Transdermal penetration of zalcitabine, lamivudine and synthesised N-acyl lamivudine esters
    Gerber, Minja
    Breytenbach, Jaco C.
    du Plessis, Jeanetta
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2008, 351 (1-2) : 186 - 193
  • [10] EPSILON-AMINOCAPROIC ACID-ESTERS AS TRANSDERMAL PENETRATION ENHANCING AGENTS
    DOLEZAL, P
    HRABALEK, A
    SEMECKY, V
    PHARMACEUTICAL RESEARCH, 1993, 10 (07) : 1015 - 1019
12345