Approach to N-aryl pyrroles via diphenyl phosphate-catalyzed [1,5]-Hydride shift/isomerization reaction with indoles

被引：6
|
作者：
Lei, Xiantao
Xie, Hong-Yan
Chen, Si-Yuan
Teng, Kai-Shun
Wen, Xiaoan
Xu, Qing-Long [1 ]
Sun, Hongbin
机构：
[1] China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, Nanjing 210009, Jiangsu, Peoples R China
来源：
TETRAHEDRON | 2015年 / 71卷 / 24期
基金：
中国国家自然科学基金;
关键词：
C-H functionalization; N-aryl pyrrole; Indole; 1,5]-Hydride shift; H BOND FUNCTIONALIZATION; INTRAMOLECULAR REDOX REACTION; ASYMMETRIC-SYNTHESIS; ALKYNYL ETHERS; CYCLIC AMINALS; CONSTRUCTION; CYCLIZATION; ACTIVATION; AMINATION; TETRAHYDROQUINOLINES;
D O I：
10.1016/j.tet.2015.04.112
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general method to synthesize N-aryl pyrrole derivatives was realized via the reactions of 2-(3-pyrroline-1-yl)arylaldehydes with indoles under acidic conditions, which underwent [1,5]-hydride shift/isomerization process. The desired products could be obtained in good to high yields with a wide substrate scope. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4098 / 4101
页数：4
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