Retrospective Analysis of Concurrent Chemoradiation with Triweekly Cisplatin plus 5-Fluorouracil Versus Weekly Cisplatin in Cervical Cancer

被引：2
|
作者：
Sonoda, Kenzo [1 ]
Yahata, Hideaki [1 ]
Ichinoe, Akimasa [1 ]
Okugawa, Kaoru [1 ]
Kaneki, Eisuke [1 ]
Kawano, Yoshiaki [1 ]
Kenjo, Hironori [1 ]
Ohgami, Tatsuhiro [1 ]
Yagi, Hiroshi [1 ]
Ohga, Saiji [2 ]
Asai, Kaori [2 ]
Nakamura, Katsumasa [2 ]
Honda, Hiroshi [2 ]
Kato, Kiyoko [1 ]
机构：
[1] Kyushu Univ, Dept Obstet & Gynecol, Grad Sch Med Sci, Fukuoka 8128582, Japan
[2] Kyushu Univ, Dept Clin Radiol, Grad Sch Med Sci, Fukuoka 8128582, Japan
来源：
ANTICANCER RESEARCH | 2015年 / 35卷 / 06期
关键词：
Cervical cancer; concurrent chemoradiation; survival; RATE INTRACAVITARY BRACHYTHERAPY; GYNECOLOGIC-ONCOLOGY-GROUP; TERM-FOLLOW-UP; UTERINE CERVIX; RADIATION-THERAPY; PELVIC RADIATION; RANDOMIZED-TRIAL; PHASE-II; CHEMORADIOTHERAPY; CARCINOMA;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background/Aim: Concurrent chemoradiation (CCRT) is the standard treatment for locally advanced cervical cancer. The purpose of the study was to compare the outcomes of triweekly cisplatin plus 5-fluorouracil and weekly cisplatin regimens. Patients and Methods: We retrospectively reviewed data from 91 patients with stage IB1-IVA cervical cancer. Results: Out of 91 patients, 48 received triweekly CCRT and 43 received weekly CCRT. For triweekly CCRT, patients received a median of two chemotherapy cycles and median total doses of cisplatin and 5-fluorouracil were 210 mg/body and 8,525 mg/body, respectively. For weekly CCRT, patients received a median of five chemotherapy cycles and the median total dose of cisplatin was 252 mg/body. No statistically significant differences in overall survival or progression-free survival were noted between the two groups. Conclusion: Both triweekly CCRT and weekly CCRT appear to have similar efficacy for cervical cancer patients, but the toxicities were better tolerable in weekly CCRT.
引用
收藏
页码：3447 / 3454
页数：8
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