Weekly Versus Triweekly Cisplatin- Based Chemotherapy Concurrent With Radiotherapy in the Treatment of Cervical Cancer A Meta-Analysis

被引:24
|
作者
Chen, Xingxing [1 ]
Zou, Haizhou [2 ]
Li, Huifang [1 ]
Lin, Ruifang [1 ]
Su, Meng [1 ]
Zhang, Wenyi [1 ]
Zhou, Yongqiang [1 ]
Zhang, Ping [1 ]
Hou, Meng [1 ]
Deng, Xia [1 ]
Zou, Changlin [1 ]
机构
[1] Wenzhou Med Univ, Dept Chemoradiat Oncol, Affiliated Hosp 1, 2 Fuxue St, Wenzhou 325000, Zhejiang, Peoples R China
[2] Wenzhou Hosp Tradit Chinese Med, Dept Oncol, Wenzhou, Zhejiang, Peoples R China
关键词
Cervical cancer; Chemoradiotherapy; Cisplatin; Weekly; Triweekly; SQUAMOUS-CELL CARCINOMA; RADIATION-THERAPY; PELVIC RADIATION; RANDOMIZED-TRIAL; UTERINE CERVIX; CLINICAL-TRIAL; FLUOROURACIL; IRRADIATION; COMBINATION; HYDROXYUREA;
D O I
10.1097/IGC.0000000000000883
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: The aim of this study was to evaluate toxicity, compliance, recurrence and the survival of weekly and triweekly cisplatin-based concomitant chemoradiation in treatment of cervical cancer. Materials and Methods: The databases were searched from 1995 until 2015 to identify eligible studies on weekly versus triweekly cisplatin chemoradiotherapy. The data were analyzed by RevMan 5.3 software. Results: A total of 5 randomized controlled trials were included in this review. Weekly cisplatin regimen significantly reduced the incidence of Hematologic toxicity. However, there was no significantly different between the 2 arms in compliance, recurrence and the survival rate (all P > 0.05). Conclusions: Weekly cisplatin regimen had the similar therapeutic effect as the triweekly cisplatin regimen but with less hematologic toxicity. Therefore, we recommend the weekly cisplatin 30 to 40 mg/m(2) chemoradiotherapy as the strong candidate for the optimal cisplatin dose and dosing schedule in the treatment of locally advanced cervical cancer.
引用
收藏
页码:344 / 349
页数:6
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