Development of ointment with antimicrobial activity from plant materials and its study

Antibiotic resistance and side effects of drugs are the current concerns of mankind. Therefore, studies aimed at finding and creating new drugs with antibiotic activity from plant materials are of high relevance. The authors formulated the composition of an ointment that contains extracts from Cetraria islandica (Icelandic moss), sphagnum and propolis for treatment of purulent wounds, and determined its pH and bioavailability in vivo. The antimicrobial activity of the ointment was studied on experimental animals. To analyze the morphological features of the wound process, three groups of animals were formed: group 1, control without treatment; group 2, treatment of the wound with Levomekol ointment; experimental group 3, treatment of the wound with ointment that consists of Icelandic moss, sphagnum and propolis. Each group included 10 animals. The ointment for treatment of purulent wounds was developed on lipophilic base with optimal pH of 5.3, antibacterial activity against both gram-positive and gram-negative microorganisms, and it can be used in phases 1 and 2 of the wound process. It has a more pronounced therapeutic effect compared with Levomekol ointment, and facilitates earlier regeneration.