Silver-catalyzed [3+2] domino reaction: an efficient strategy to synthesize imidazole-5-carbaldehydes

被引：11

作者：

Wang, Changcheng ^{[1
,2
]}

Jiang, Hangqi ^{[1
,2
]}

Chen, Weifeng ^{[1
,2
]}

Dong, Jun ^{[3
]}

Chen, Zhengwang ^{[4
]}

Cao, Hua ^{[1
,2
]}

机构：

[1] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Zhongshan 528458, Peoples R China

[2] Guangdong Pharmaceut Univ, Guangdong Cosmet Engn & Technol Res Ctr, Zhongshan 528458, Peoples R China

[3] Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou 510006, Guangdong, Peoples R China

[4] Gannan Normal Univ, Key Lab Organopharmaceut Chem Jiangxi Prov, Ganzhou 341000, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 31期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; HIGHLY SUBSTITUTED IMIDAZOLES; ONE-POT; REGIOSELECTIVE SYNTHESIS; MOLECULAR-OXYGEN; TETRASUBSTITUTED IMIDAZOLES; DIRECT ARYLATION; METAL-FREE; MULTICOMPONENT SYNTHESIS; 3-COMPONENT REACTION;

D O I：

10.1039/c7ob01242j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented regioselective silver-catalyzed [3 + 2] domino reaction of amidines and ynals for the formation of C-N bonds has been developed. The reaction provided a new route to prepare imidazole-5-carbaldehydes which are important intermediates for the construction of fine chemicals. The reaction proceeds smoothly with a broad range of substrates to give imidazoles in good yields.

引用

页码：6463 / 6466

页数：4

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