Silver-catalyzed [3+2] domino reaction: an efficient strategy to synthesize imidazole-5-carbaldehydes

被引：11
|
作者：
Wang, Changcheng [1 ,2 ]
Jiang, Hangqi [1 ,2 ]
Chen, Weifeng [1 ,2 ]
Dong, Jun [3 ]
Chen, Zhengwang [4 ]
Cao, Hua [1 ,2 ]
机构：
[1] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Zhongshan 528458, Peoples R China
[2] Guangdong Pharmaceut Univ, Guangdong Cosmet Engn & Technol Res Ctr, Zhongshan 528458, Peoples R China
[3] Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou 510006, Guangdong, Peoples R China
[4] Gannan Normal Univ, Key Lab Organopharmaceut Chem Jiangxi Prov, Ganzhou 341000, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 31期
基金：
中国国家自然科学基金;
关键词：
C-H BONDS; HIGHLY SUBSTITUTED IMIDAZOLES; ONE-POT; REGIOSELECTIVE SYNTHESIS; MOLECULAR-OXYGEN; TETRASUBSTITUTED IMIDAZOLES; DIRECT ARYLATION; METAL-FREE; MULTICOMPONENT SYNTHESIS; 3-COMPONENT REACTION;
D O I：
10.1039/c7ob01242j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An unprecedented regioselective silver-catalyzed [3 + 2] domino reaction of amidines and ynals for the formation of C-N bonds has been developed. The reaction provided a new route to prepare imidazole-5-carbaldehydes which are important intermediates for the construction of fine chemicals. The reaction proceeds smoothly with a broad range of substrates to give imidazoles in good yields.
引用
收藏
页码：6463 / 6466
页数：4
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