Retroviruses as tools to study the immune system

被引：29
|
作者：
Lois, C
Refaeli, Y
Qin, XF
Van Parijs, L
机构：
[1] MIT, Dept Biol, Ctr Canc Res, Cambridge, MA 02139 USA
[2] Univ Calif San Francisco, George Williams Hooper Fdn, San Francisco, CA 94143 USA
[3] CALTECH, Dept Biol, Pasadena, CA 91125 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 04期
关键词：
D O I：
10.1016/S0952-7915(00)00247-8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Retrovirus-based vectors provide an efficient means to introduce and express genes in cells of the immune system and have become a popular tool to study immune function. They are easy to manipulate and provide stable, long-term gene expression because they integrate into the genome. Current retroviral vectors do have limitations that affect their usefulness in certain applications. However. recent advances suggest a number of ways in which these vectors might be improved to extend their utility in immunological research.
引用
收藏
页码：496 / 504
页数：9
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