Structure-activity relationship of in vitro antiviral and cytotoxic activity of semisynthetic analogues of scopadulane diterpenes

被引：14

作者：

Betancur-Galvis, L

Zuluaga, C

Arnó, M

González, MA

Zaragozá, RJ

机构：

[1] Univ Antioquia, Grp Inmunovirol Biogenesis, Medellin, Colombia

[2] Univ Valencia, Dept Quim Organ, E-46100 Burjassot, Valencia, Spain

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 10期

关键词：

D O I：

10.1021/np010207l

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Fourteen semisynthetic compounds derived from the natural scopadulane-type diterpenes thyrsiflorin A (4), B (5), and C (6), including several precursors, have been examined in vitro for their antiherpetic activity against Herpes simplex virus type II (HSV-2) and cytotoxicity against two human tumor cell lines. Four of these compounds showed moderate antiherpetic activity, but none of them exhibited a significant cytotoxicity against the cell lines used. Some structure-activity relationships have been identified for the antiviral activity in these scopadulane derivatives as well as important structural features for the cytotoxic activity.

引用

页码：1318 / 1321

页数：4

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