Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives

被引：148

作者：

Roe, M ^{[1
]}

Folkes, A ^{[1
]}

Ashworth, P ^{[1
]}

Brumwell, J ^{[1
]}

Chima, L ^{[1
]}

Hunjan, S ^{[1
]}

Pretswell, I ^{[1
]}

Dangerfield, W ^{[1
]}

Ryder, H ^{[1
]}

Charlton, P ^{[1
]}

机构：

[1] Xenova Ltd, Slough SL1 4EF, Berks, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(99)00030-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have synthesised and evaluated a series of anthranilamide based modulators of P-glycoprotein. These studies have identified XR9576(2), a potent inhibitor of P-glycoprotein in vitro and in vivo. The general synthesis and the SAR of these compounds are described. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：595 / 600

页数：6

共 50 条

[21] Mechanism of multidrug resistance to chemotherapy mediated by P-glycoprotein (Review)
Tian, Yichen
Lei, Yongrong
Wang, Yani
Lai, Jiejuan
Wang, Jianhua
Xia, Feng
INTERNATIONAL JOURNAL OF ONCOLOGY, 2023, 63 (05)
[22] Strategies to overcome or circumvent P-glycoprotein mediated multidrug resistance
Yuan, Hongyu
Li, Xun
Wu, Jifeng
Li, Jinpei
Qu, Xianjun
Xu, Wenfang
Tang, Wei
CURRENT MEDICINAL CHEMISTRY, 2008, 15 (05) : 470 - 476
[23] MOLECULAR-BASIS OF MULTIDRUG RESISTANCE MEDIATED BY P-GLYCOPROTEIN
HIGGINS, CF
CURRENT OPINION IN BIOTECHNOLOGY, 1991, 2 (02) : 278 - 281
[24] MULTIDRUG-RESISTANCE MEDIATED BY P-GLYCOPROTEIN IN HEMATOLOGICAL MALIGNANCIES
PASMAN, PC
SCHOUTEN, HC
NETHERLANDS JOURNAL OF MEDICINE, 1993, 42 (5-6): : 218 - 231
[25] P-glycoprotein mediated multidrug resistance and its implications for pathology
Trambas, CM
Muller, HK
Woods, GM
PATHOLOGY, 1997, 29 (02) : 122 - 130
[26] Bacterial multidrug resistance mediated by a homologue of the human multidrug transporter P-glycoprotein
Konings, WN
Poelarends, GJ
IUBMB LIFE, 2002, 53 (4-5) : 213 - 218
[27] Reversal of P-glycoprotein mediated vincristine resistance by analogues of pentoxifylline
Breier, A.
Kupsakova, I.
Barancik, M.
Docolomansky, P.
Rybar, A.
FEBS JOURNAL, 2006, 273 : 230 - 230
[28] P-Glycoprotein Mediated Multidrug Resistance Reversal by Phytochemicals: A Review of SAR & Future Perspective for Drug Design
Syed, Safiulla Basha
Coumar, Mohane Selvaraj
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2016, 16 (22) : 2484 - 2508
[29] Combinatorial libraries of non-natural polyenes for reversal of P-glycoprotein mediated multidrug resistance.
Turner, TM
Andrus, MB
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 223 : B191 - B191
[30] MULTIDRUG RESISTANCE DUE TO P-GLYCOPROTEIN
BURT, RK
FOJO, AT
THORGEIRSSON, SS
HOSPITAL PRACTICE, 1990, 25 (04): : 67 - &

← 1 2 3 4 5 →