Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives

被引：148

作者：

Roe, M ^{[1
]}

Folkes, A ^{[1
]}

Ashworth, P ^{[1
]}

Brumwell, J ^{[1
]}

Chima, L ^{[1
]}

Hunjan, S ^{[1
]}

Pretswell, I ^{[1
]}

Dangerfield, W ^{[1
]}

Ryder, H ^{[1
]}

Charlton, P ^{[1
]}

机构：

[1] Xenova Ltd, Slough SL1 4EF, Berks, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(99)00030-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have synthesised and evaluated a series of anthranilamide based modulators of P-glycoprotein. These studies have identified XR9576(2), a potent inhibitor of P-glycoprotein in vitro and in vivo. The general synthesis and the SAR of these compounds are described. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：595 / 600

页数：6

共 50 条

[1] Reversal of P-glycoprotein mediated multidrug resistance by Cryptotanshinone and Dihydrotanshinone
Hu, Tao
Yeung, John H. K.
Wang, Lin
Zhou, Xuelin
Or, Penelope M. Y.
To, Kenneth K. W.
Cho, Chi Hin
FASEB JOURNAL, 2013, 27
[2] Reversal of P-glycoprotein associated multidrug resistance by new isoprenoid derivatives
Hayashi, M
Koike, K
Rho, MC
Kuwano, M
Kishiye, T
Komiyama, K
ANTI-CANCER DRUG DESIGN, 2001, 16 (4-5): : 255 - 260
[3] Inhibition of P-Glycoprotein Mediated Multidrug Resistance by Stemofoline Derivatives
Umsumarng, Sonthaya
Pintha, Komsak
Pitchakarn, Pornsiri
Sastraruji, Kwankamol
Sastraruji, Thanapat
Ung, Alison T.
Jatisatienr, Araya
Pyne, Stephen G.
Limtrakul, Pornngarm
CHEMICAL & PHARMACEUTICAL BULLETIN, 2013, 61 (04) : 399 - 404
[4] Novel betulin derivatives as multidrug reversal agents targeting P-glycoprotein
Laiolo, Jeronimo
Graikioti, Dafni G.
Barbieri, Cecilia L.
Joray, Mariana B.
Antoniou, Antonia I.
Vera, D. Mariano A.
Athanassopoulos, Constantinos M.
Carpinella, Maria C.
SCIENTIFIC REPORTS, 2024, 14 (01)
[5] Novel betulin derivatives as multidrug reversal agents targeting P-glycoprotein
Jerónimo Laiolo
Dafni G. Graikioti
Cecilia L. Barbieri
Mariana B. Joray
Antonia I. Antoniou
D. Mariano A. Vera
Constantinos M. Athanassopoulos
María C. Carpinella
Scientific Reports, 14
[6] Synthesis and bioevaluation of novel benzodipyranone derivatives as P-glycoprotein inhibitors for multidrug resistance reversal agents
Chen, Chien-Yu
Liu, Nai-Yu
Lin, Hui-Chang
Lee, Chih-Yu
Hung, Chin-Chuan
Chang, Chih-Shiang
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 118 : 219 - 229
[7] NOVEL STRATEGIES AGAINST MULTIDRUG RESISTANCE MEDIATED BY P-GLYCOPROTEIN
Casco, S.
Soto-Vega, E.
DRUGS OF THE FUTURE, 2016, 41 (03) : 169 - 175
[8] Identification of Novel Inhibitors of P-glycoprotein Mediated Multidrug Resistance
Follit, Courtney A.
McCormick, James W.
Nanayakkara, Amila K.
Wise, John G.
Vogel, Pia D.
FASEB JOURNAL, 2017, 31
[9] Reversal of P-glycoprotein mediated multidrug resistance in vivo by XR9576
Mistry, P
Bootie, D
Liddle, C
Loi, R
Templeton, D
ANNALS OF ONCOLOGY, 1998, 9 : 148 - 148
[10] Reversal of multidrug resistance by novel inhibitors of human P-glycoprotein in cell culture
Follit, Courtney
Brewer, Fran
Vogel, Pia
Wise, John
FASEB JOURNAL, 2014, 28 (01):

← 1 2 3 4 5 →