α-Glucosidase Inhibitory Activity and Anti-Adipogenic Effect of Compounds from Dendrobium delacourii

被引：8
|
作者：
Thant, May Thazin [1 ,2 ]
Khine, Hnin Ei Ei [3 ]
Nealiga, Justin Quiel Lasam [3 ]
Chatsumpun, Nutputsorn [4 ]
Chaotham, Chatchai [3 ,5 ]
Sritularak, Boonchoo [1 ,6 ]
Likhitwitayawuid, Kittisak [1 ]
机构：
[1] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Pharmaceut Bot, Bangkok 10330, Thailand
[2] Univ Pharm, Dept Pharmacognosy, Yangon 11031, Myanmar
[3] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Biochem & Microbiol, Bangkok 10330, Thailand
[4] Mahidol Univ, Fac Pharm, Dept Pharmacognosy, Bangkok 10400, Thailand
[5] Chulalongkorn Univ, Fac Pharmaceut Sci, Preclin Toxic & Efficacy Assessment Med & Chem Re, Bangkok 10330, Thailand
[6] Chulalongkorn Univ, Fac Pharmaceut Sci, Nat Prod Ageing & Chron Dis Res Unit, Bangkok 10330, Thailand
来源：
MOLECULES | 2022年 / 27卷 / 04期
关键词：
Dendrobium delacourii; Orchidaceae; alpha-glucosidase; anti-adipogenic; densifloral B; phoyunnanin E; phoyunnanin C; ACTIVATED PROTEIN-KINASE; ADIPOCYTE DIFFERENTIATION; PHOLIDOTA-YUNNANENSIS; 3T3-L1; CONSTITUENTS; AMPK;
D O I：
10.3390/molecules27041156
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chemical investigation of Dendrobium delacourii revealed 11 phenolic compounds, and the structures of these compounds were determined by analysis of their NMR and HR-ESI-MS data. All compounds were investigated for their alpha-glucosidase inhibitory activity and anti-adipogenic properties. Phoyunnanin E (10) and phoyunnanin C (11) showed the most potent alpha-glucosidase inhibition by comparing with acarbose, which was used as a positive control. Kinetic study revealed the non-competitive inhibitors against the enzyme. For anti-adipogenic activity, densifloral B (3) showed the strongest inhibition when compared with oxyresveratrol (positive control). In addition, densifloral B might be responsible for the inhibition of adipocyte differentiation via downregulating the expression of peroxisome proliferator-activated receptor gamma (PPAR gamma) and CCAAT enhancer-binding protein alpha (C/EBP alpha), which are major transcription factors in adipogenesis.
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页数：17
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