Gold Nanoparticles Modified Electrode for the Determination of an Antihypertensive Drug

被引：22

作者：

Atta, Nada F. ^{[1
]}

Galal, Ahmed ^{[1
]}

Azab, Shereen M. ^{[1
]}

机构：

[1] Cairo Univ, Fac Sci, Dept Chem, Giza 12613, Egypt

来源：

ELECTROANALYSIS | 2012年 / 24卷 / 06期

关键词：

Terazosin; Gold nanoparticles; Electrochemical sensor; Impedance spectroscopy; PERFORMANCE LIQUID-CHROMATOGRAPHY; BENIGN PROSTATIC HYPERPLASIA; SPECTROPHOTOMETRIC DETERMINATION; TERAZOSIN HYDROCHLORIDE; GLASSY-CARBON; ELECTROCHEMICAL BIOSENSOR; OXIDE ELECTRODE; HUMAN PLASMA; PRAZOSIN; FILM;

D O I：

10.1002/elan.201200169

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The nature of binding between Terazosin (TR) and gold nanoparticles (Au-Nps) is investigated using UV-vis and fluorescence spectroscopies, cyclic voltammetry, SEM, and EIS. The results suggest that Au-Nps are effective carriers for TR. An electrochemical sensor for TR is introduced using Au-Nps electrodeposited on carbon paste electrode. The effect of parameters including pH and scan rate on the response was investigated. A linear range from 8.0 x 10(-9) to 5.4 x 10(-5) mol?L-1 with correlation coefficient of 0.9995 and detection limit of 1.2 x 10(-10) mol?L-1 was obtained. This sensor was used for determining TR spiked in urine, and excellent recovery results are achieved.

引用

页码：1431 / 1440

页数：10

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