CAN VITAMIN A MEDIATE IMMUNITY AND INFLAMMATION?

被引：6

作者：

Spinas, E. ^{[1
]}

Saggini, A. ^{[2
]}

Kritas, S. K. ^{[3
]}

Cerulli, G. ^{[4
]}

Caraffa, A. ^{[5
]}

Antinolfi, P. ^{[5
]}

Pantalone, A. ^{[6
]}

Frydas, A. ^{[7
]}

Tei, M. ^{[4
]}

Speziali, A. ^{[4
]}

Saggini, R. ^{[8
]}

Pandolfi, F. ^{[9
]}

Conti, P. ^{[10
]}

机构：

[1] Univ Cagliari, Dept Surg & Odontostomatol Sci, I-09123 Cagliari, Italy

[2] Univ Roma Tor Vergata, Dept Dermatol, Rome, Italy

[3] Aristotle Univ Thessaloniki, Sch Vet Med, Dept Microbiol & Infect Dis, Macedonia, Greece

[4] Nicolas Fdn, Onlus, Arezzo, Italy

[5] Univ Perugia, Orthoped Div, I-06100 Perugia, Italy

[6] Univ G dAnnunzio, Orthoped Div, Chieti, Italy

[7] Aristotle Univ Thessaloniki, GR-54006 Thessaloniki, Greece

[8] G dAnnunzio Univ Chieti Pescara, Fac Med & Surg, Dept Neurosci & Imaging, Chieti, Italy

[9] Univ Cattolica Sacro Cuore, Rome, Italy

[10] Univ G dAnnunzio, Postgrad Med Sch, Div Immunol, Chieti, Italy

来源：

JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS | 2015年 / 29卷 / 01期

关键词：

vitamins; immunity; inflammation; cytokines; chemokines; CELLS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vitamins are natural components of foods and are organic compounds distinct from fat, carbohydrates and proteins. Vitamin A is the generic descriptor for compounds with the qualitative biological activity of retinol. Unlike beta-carotene, vitamin A is not an antioxidant and its benefit is related to possible boosting of immune reactions. The effect of vitamin A on immune function is wide-reaching and its deficiency appears to affect immunity in several ways. Innate and adaptive immune responses are affected in some way by lack of vitamin A. Retinoids seem to act on differentiation of lymphocytes, antibody production, phagocytosis of macrophages, NK, Treg, and T helper cell activity. In addition, in humans, signs of a vitamin A deficiency also include the dysregulation of cytokine/chemokine generation and release. However, excess of vitamin A has been demonstrated to have toxic effects in most species studied. Here we summarize some important effects of vitamin A in immunity and inflammation.

引用

页码：1 / 5

页数：5

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