Therapeutic Mechanisms of Glucocorticoids

被引：379

作者：

Vandewalle, Jolien ^{[1
,2
]}

Luypaert, Astrid ^{[3
,4
]}

De Bosscher, Karolien ^{[3
,4
]}

Libert, Claude ^{[1
,2
]}

机构：

[1] VIB, Ctr Inflammat Res, Ghent, Belgium

[2] Univ Ghent, Dept Biomed Mol Biol, Ghent, Belgium

[3] VIB Univ Ghent UGent, Nucl Receptor Lab, Receptor Res Labs, Ctr Med Biotechnol, Ghent, Belgium

[4] Univ Ghent, Dept Biochem, Ghent, Belgium

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2018年 / 29卷 / 01期

关键词：

ACTIVATED RECEPTOR-GAMMA; INDUCED LEUCINE-ZIPPER; NF-KAPPA-B; OBSTRUCTIVE PULMONARY-DISEASE; PPAR-ALPHA; DNA-BINDING; RHEUMATOID-ARTHRITIS; MEDIATED TRANSACTIVATION; INHALED CORTICOSTEROIDS; TRANSCRIPTION FACTORS;

D O I：

10.1016/j.tem.2017.10.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucocorticoids (GCs) have been used clinically for decades as potent anti-inflammatory and immunosuppressive agents. Nevertheless, their use is severely hampered by the risk of developing side effects and the occurrence of glucocorticoid resistance (GCR). Therefore, efforts to understand the complex mechanisms underlying GC function and GCR are ongoing. The goal is to generate new glucocorticoid receptor (GR) ligands that can dissociate anti-inflammatory from metabolic side effects and/or overcome GCR. In this review paper we discuss recent insights into GR-mediated actions in GCR and novel therapeutic strategies for acute and chronic inflammatory diseases.

引用

页码：42 / 54

页数：13

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