Stevens-Johnson syndrome and cholestatic hepatitis

被引:27
|
作者
Morelli, MS [1 ]
O'Brien, FX [1 ]
机构
[1] Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Gen Internal Med Sect, Winston Salem, NC 27157 USA
关键词
Stevens-Johnson syndrome; hepatitis; cholestasis; rash; skin;
D O I
10.1023/A:1012351231143
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Stevens-Johnson Syndrome (SJS) is a rare but severe dermatological condition that typically occurs after the ingestion of medications such as nonsteroidal drugs, antibiotics, and anti-convulsants. Extracutaneous manifestations of the syndrome can occur and may involve the conjunctiva, trachea, buccal mucosa, gastrointestinal tract, and genitourinary tract. Cholestatic liver disease, which may precede the skin manifestations of SJS, has been reported to occur in SJS, but the medical literature has only 10 case reports describing this phenomenon (1-9). We report the case of a 19-year-old female with SJS and cholestatic liver disease. A discussion of the underlying pathophysiology of SJS and its treatment follows.
引用
收藏
页码:2385 / 2388
页数:4
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