An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China

被引：35

作者：

Xiao, Shuifang ^{[1
]}

Li, Jinrang ^{[2
]}

Zheng, Hongliang ^{[3
]}

Yan, Yan ^{[4
]}

Li, Xiangping ^{[5
]}

Zhang, Lihong ^{[6
]}

Lv, Quiping ^{[7
]}

Zhang, Junbo ^{[1
]}

Zeng, Lin ^{[8
]}

Gao, Xia ^{[9
]}

Chen, Xiong ^{[10
,11
]}

Yang, Hui ^{[12
]}

Zhao, Chen ^{[13
]}

Zhang, Jian ^{[14
]}

Lu, Honghua ^{[15
]}

Luo, Xianyang ^{[16
]}

Wang, Guangke ^{[17
]}

Yi, Hongliang ^{[18
]}

Ye, Jin ^{[19
]}

Lin, Zhenqun ^{[20
]}

Tian, Linli ^{[21
]}

Zhang, Jingjing ^{[22
]}

Chen, Ting ^{[23
]}

Yu, Aimin ^{[24
]}

Liu, Zhaohui ^{[25
]}

Ren, Xiaoyong ^{[26
]}

Yang, Xinming ^{[27
]}

Zhang, Siyi ^{[28
]}

Cui, Xiaobo ^{[29
]}

Li, Gelin ^{[30
]}

Wan, Guanglun ^{[31
]}

Lin, Chang ^{[32
]}

Chen, Hui ^{[33
]}

Deng, Anchun ^{[34
]}

Tang, Xiabing ^{[35
]}

Zhang, Qingfeng ^{[36
,37
]}

Tao, Zhenfeng ^{[38
]}

Shi, Li ^{[39
]}

Zhou, Jianyong ^{[40
]}

Qin, Gang ^{[41
]}

Zhuang, Peiyun ^{[42
]}

Huangfu, Hui ^{[43
]}

Yang, Jianming ^{[44
]}

Zhou, Guojin ^{[45
]}

Li, Huijun ^{[46
]}

Wu, Wei ^{[47
]}

Li, Julan ^{[48
]}

Li, Shuhua ^{[49
]}

Lou, Guangming ^{[50
]}

Fang, Hongyan ^{[51
]}

机构：

[1] Peking Univ, Dept Otorhinolaryngol Head & Neck Surg, Hosp 1, 8 Xishiku St, Beijing 100034, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, Dept Otorhinolaryngol Head & Neck Surg, Med Ctr 6, 6 Fucheng Rd, Beijing 100048, Peoples R China

[3] Second Mil Med Univ, Changhai Hosp, Dept Otorhinolaryngol Head & Neck Surg, 168 Changhai St, Shanghai 200433, Peoples R China

[4] Peking Univ, Dept Otorhinolaryngol Head & Neck Surg, Hosp 3, Beijing, Peoples R China

[5] Southern Med Univ, Nanfang Hosp, Dept Otorhinolaryngol Head & Neck Surg, Guangzhou, Guangdong, Peoples R China

[6] Peking Univ, Dept Otorhinolaryngol Head & Neck Surg, Peoples Hosp, Beijing, Peoples R China

[7] China Japan Friendship Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing, Peoples R China

[8] Peking Univ, Hosp 3, Res Ctr Clin Epidemiol, Beijing, Peoples R China

[9] Nanjing Univ, Affiliated Drum Tower Hosp, Dept Otorhinolaryngol Head & Neck Surg, Med Sch, Nanjing, Jiangsu, Peoples R China

[10] Wuhan Univ, Dept Otorhinolaryngol Head & Neck Surg, Zhongnan Hosp, Wuhan, Hubei, Peoples R China

[11] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Otorhinolaryngol Head & Neck Surg, Wuhan, Hubei, Peoples R China

[12] Sichuan Univ, Dept Otorhinolaryngol Head & Neck Surg, West China Hosp, Chengdu, Sichuan, Peoples R China

[13] China Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Affiliated Hosp 1, Shenyang, Liaoning, Peoples R China

[14] Nanchang Univ, Dept Otorhinolaryngol Head & Neck Surg, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China

[15] Tianjin First Cent Hosp, Dept Otorhinolaryngol Head & Neck Surg, Tianjin, Peoples R China

[16] Xiamen Univ, Dept Otorhinolaryngol Head & Neck Surg, Affiliated Hosp 1, Xiamen, Fujian, Peoples R China

[17] Henan Prov Peoples Hosp, Dept Otorhinolaryngol Head & Neck Surg, Zhengzhou, Henan, Peoples R China

[18] Shanghai Jiao Tong Univ, Dept Otorhinolaryngol Head & Neck Surg, Affiliated Peoples Hosp 6, Shanghai, Peoples R China

[19] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Otorhinolaryngol Head & Neck Surg, Guangzhou, Guangdong, Peoples R China

[20] Hainan Prov Peoples Hosp, Dept Otorhinolaryngol Head & Neck Surg, Hiakou, Hainan, Peoples R China

[21] Harbin Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Affiliated Hosp 2, Harbin, Heilongjiang, Peoples R China

[22] Peking Univ, Dept Otorhinolaryngol Head & Neck Surg, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China

[23] Fujian Prov Hosp, Dept Otorhinolaryngol Head & Neck Surg, Fuzhou, Fujian, Peoples R China

[24] Yangzhou Univ, Dept Otorhinolaryngol Head & Neck Surg, Clin Med Sch, Yangzhou, Jiangsu, Peoples R China

[25] Zunyi Med Coll, Dept Otorhinolaryngol Head & Neck Surg, Affiliated Hosp, Zunyi, Guizhou, Peoples R China

[26] Xi An Jiao Tong Univ, Dept Otorhinolaryngol Head & Neck Surg, Affiliated Hosp 2, Xian, Shaanxi, Peoples R China

[27] Cent South Univ, Xiangya Hosp 2, Dept Otorhinolaryngol Head & Neck Surg, Changsha, Hunan, Peoples R China

[28] Guangdong Prov Peoples Hosp, Dept Otorhinolaryngol Head & Neck Surg, Guangzhou, Guangdong, Peoples R China

[29] Inner Mongolia Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Affiliated Hosp, Hohhot, Inner Mongolia, Peoples R China

[30] Capital Med Univ, Beijing Friendship Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing, Peoples R China

[31] Univ Sci & Technol China, Anhui Prov Hosp, Div Life Sci & Med, Dept Otolaryngol Head & Neck Surg,Affiliated Hosp, Hefei, Anhui, Peoples R China

[32] Fujian Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Affiliated Hosp 1, Fuzhou, Fujian, Peoples R China

[33] Chengdu First Peoples Hosp, Dept Otorhinolaryngol Head & Neck Surg, Chengdu, Sichuan, Peoples R China

[34] Army Mil Med Univ, Xinqiao Hosp, Dept Otorhinolaryngol Head & Neck Surg, Chongqing, Peoples R China

[35] Wuxi Peoples Hosp, Dept Otorhinolaryngol Head & Neck Surg, Wuxi, Jiangsu, Peoples R China

[36] Dalian Cent Hosp, Dept Otorhinolaryngol Head & Neck Surg, Dalian, Liaoning, Peoples R China

[37] Shenzhen Univ, Dept Otorhinolaryngol Head & Neck Surg, Gen Hosp, Shenzhen, Guangdong, Peoples R China

[38] Bethune Int Peace Hosp, Dept Otorhinolaryngol Head & Neck Surg, Shijiazhuang, Hebei, Peoples R China

[39] Air Force Mil Med Univ, Xijing Hosp, Dept Otorhinolaryngol Head & Neck Surg, Xian, Shaanxi, Peoples R China

[40] Jiangmen Cent Hosp, Dept Otorhinolaryngol Head & Neck Surg, Jiangmen, Guangdong, Peoples R China

[41] Southwest Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Affiliated Hosp, Luzhou, Sichuan, Peoples R China

[42] Xiamen Univ, Zhongshan Hosp, Dept Otorhinolaryngol Head & Neck Surg, Xiamen, Fujian, Peoples R China

[43] Shanxi Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Hosp 1, Taiyuan, Shanxi, Peoples R China

[44] Anhui Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Affiliated Hosp 2, Hefei, Anhui, Peoples R China

[45] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Otorhinolaryngol Head & Neck Surg, Hangzhou, Zhejiang, Peoples R China

[46] Harbin Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China

[47] PLA Strateg Support Force Characterist Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Beijing, Peoples R China

[48] Chinese Peoples Armed Police Force, Dept Otorhinolaryngol Head & Neck Surg, Sichuan Prov Corps Hosp, Leshan, Sichuan, Peoples R China

[49] Gen Hosp Northern Theater Command, Dept Otorhinolaryngol Head & Neck Surg, Shenyang, Liaoning, Peoples R China

[50] First Hosp Longyan City, Dept Otorhinolaryngol Head & Neck Surg, Longyan, Fujian, Peoples R China

来源：

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 2020年 / 277卷 / 10期

关键词：

Laryngopharyngeal reflux; Multi-center; Cross-sectional survey; Otorhinolaryngology; GASTROESOPHAGEAL-REFLUX; SYMPTOM INDEX; RELIABILITY; PREVALENCE; MANAGEMENT; PEPSIN; PH;

D O I：

10.1007/s00405-020-06045-0

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Purpose Using the Reflux Symptom Index (RSI), this nationwide study aimed to investigate the incidence, diagnostic status, risk factors, and common symptoms of adult laryngopharyngeal reflux disease (LPRD) at otorhinolaryngology-head and neck surgery (OHNS) clinics in China. Methods This multicenter cross-sectional survey began at the different institutions ranged from July to October 2017, and the duration was 12 months. A total of 90,440 eligible patients were finally enrolled from 72 medical institutions in China. All these patients completed the questionnaire based on RSI. In this study, LPRD was defined as RSI > 13. Results There were 9182 with LPRD among the 90,440 eligible participants (10.15%). However, only 1294 had a history of LPRD diagnosis among those with LPRD (14.09%). There were regional differences in the frequency of LPRD (P < 0.001). The proportions of patients with LPRD in males (vs. females), middle- and old-aged patients (vs. young), with current smoking history (vs. no smoking), and current drinking history (vs. no drinking) were significantly higher (all P < 0.001). Middle and old age, current smoking, and drinking history were independent predictors of LPRD (all P < 0.001, OR 1.240, 1.261, and 1.481, respectively). "Sensations of something stuck in throat or a lump in throat", "clearing throat", and "excess throat mucus or postnasal drip" were the most frequent clinical symptoms in patients with LPRD. Conclusions LPRD has a high incidence at the OHNS clinics in China. However, the diagnostic status of this disease is not optimistic. Older age, smoking, and drinking history were risk factors for LPRD.

引用

页码：2829 / 2838

页数：10

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