Toward cellular and tissue selective inhibition of histone deacetylases (HDAC): Development of cellular- and isoform-selective HDAC probes

被引:0
|
作者
Petukhov, Pavel [2 ]
Hanigan, Thomas [1 ]
Kastrati, Irida [3 ]
Frasor, Jonna [3 ]
机构
[1] Univ Illinois, Med Chem, Chicago, IL USA
[2] Univ Illinois, Med Chem & Pharmacognosy, Chicago, IL USA
[3] Univ Illinois, Physiol & Biophys, Chicago, IL USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
214
引用
收藏
页数:1
相关论文
共 50 条
  • [31] Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntingtons disease mice: implications for the ubiquitinproteasomal and autophagy systems
    Jia, Haiqun
    Kast, Ryan J.
    Steffan, Joan S.
    Thomas, Elizabeth A.
    [J]. HUMAN MOLECULAR GENETICS, 2012, 21 (24) : 5280 - 5293
  • [32] Novel and selective inhibitors of histone deacetylases (HDAC) 1 and 2 significantly enhance the activity of the DNA methyltransferase inhibitor azacitidine in acute myeloid leukemia (AML)
    Min, Chengyin
    Quayle, Steven N.
    Tamang, David
    Jones, Simon S.
    Yang, Min
    [J]. CANCER RESEARCH, 2015, 75
  • [33] Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents
    Namdar, Mandana
    Perez, Gisela
    Ngo, Lang
    Marks, Paul A.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (46) : 20003 - 20008
  • [34] Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants
    Marek, Martin
    Shaik, Tajith B.
    Heimburg, Tino
    Chakrabarti, Alokta
    Lancelot, Julien
    Ramos-Morales, Elizabeth
    Da Veiga, Cyrielle
    Kalinin, Dmitrii
    Melesina, Jelena
    Robaa, Dina
    Schmidtkunz, Karin
    Suzuki, Takayoshi
    Holl, Ralph
    Ennifar, Eric
    Pierce, Raymond J.
    Jung, Manfred
    Sippl, Wolfgang
    Romier, Christophe
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (22) : 10000 - 10016
  • [35] Methionine 274 Is Not the Determining Factor for Selective Inhibition of Histone Deacetylase 8 (HDAC8) by L-Shaped Inhibitors
    Jansch, Niklas
    Lang, Kim Leoni
    Meyer-Almes, Franz-Josef
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (19)
  • [36] Identification of Novel, Selective, and Stable Inhibitors of Class II Histone Deacetylases. Validation Studies of the Inhibition of the Enzymatic Activity of HDAC4 by Small Molecules as a Novel Approach for Cancer Therapy
    Ontoria, Jesus M.
    Altamura, Sergio
    Di Marco, Annalise
    Ferrigno, Federica
    Laufer, Ralph
    Muraglia, Ester
    Palumbi, Maria Cecilia
    Rowley, Michael
    Scarpelli, Rita
    Schultz-Fademrecht, Carsten
    Scrafini, Sergio
    Steinkuehler, Christian
    Jones, Philip
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (21) : 6782 - 6789
  • [37] Chimerically designed HDAC- and tyrosine kinase inhibitors. A series of erlotinib hybrids as dual-selective inhibitors of EGFR, HER2 and histone deacetylases
    Beckers, Thomas
    Mahboobi, Siavosh
    Sellmer, Andreas
    Winkler, Matthias
    Eichhorn, Emerich
    Pongratz, Herwig
    Maier, Thomas
    Ciossek, Thomas
    Baer, Thomas
    Kelter, Gerhard
    Fiebig, Heinz-Herbert
    Schmidt, Mathias
    [J]. MEDCHEMCOMM, 2012, 3 (07) : 829 - 835
  • [38] Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout br
    Steimbach, Raphael R.
    Herbst-Gervasoni, Corey J.
    Lechner, Severin
    Stewart, Tracy Murray
    Klinke, Glynis
    Ridinger, Johannes
    Geraldy, Magalie N. E.
    Tihanyi, Gergely
    Foley, Jackson R.
    Uhrig, Ulrike
    Kuster, Bernhard
    Poschet, Gernot
    Casero, Robert A., Jr.
    Medard, Guillaume
    Oehme, Ina
    Christianson, David W.
    Gunkel, Nikolas
    Miller, Aubry K.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2022, 144 (41) : 18861 - 18875
  • [39] Identification of Molecular Interactions within Histone Deacetylase Isozymes for the Development of Selective HDAC2 Inhibitors for the Design of Targeted Cancer Therapies
    May, Xavier
    Watkins, Davita
    Stoddard, Shana V.
    [J]. FASEB JOURNAL, 2017, 31
  • [40] Discovery of novel isoform-selective histone deacetylases 5 and 9 inhibitors through combined ligand-based pharmacophore modeling, molecular mocking, and molecular dynamics simulations for cancer treatment
    Elmezayen, Ammar D.
    Al-Obaidi, Anas
    Yelekci, Kemal
    [J]. JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2021, 106