The Mx GTPase family of interferon-induced antiviral proteins

被引：154
|
作者：
Haller, Otto [1 ]
Stertz, Silke [1 ]
Kochs, Georg [1 ]
机构：
[1] Univ Freiburg, Inst Med Mikrobiol & Hyg, Abt Virol, D-79008 Freiburg, Germany
来源：
MICROBES AND INFECTION | 2007年 / 9卷 / 14-15期
关键词：
interferon; MxGTPase; dynamin; influenza virus; bunyaviruses; PML nuclear bodies; SUMO-1; endoplasmic reticulum;
D O I：
10.1016/j.micinf.2007.09.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mx proteins are interferon-induced members of the dynamin superfamily of large GTPases. They inhibit a wide range of viruses by blocking an early stage of the replication cycle. Studies in genetically defined mouse strains highlight their powerful action in early antiviral host defence. (c) 2007 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：1636 / 1643
页数：8
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