Pyrrolopyrrole aza-BODIPY near-infrared photosensitizer for dual-mode imaging-guided photothermal cancer therapy

被引：45

作者：

Wu, Chaolong ^{[1
,2
]}

Huang, Xiaoyu ^{[1
,2
]}

Tang, Yunyun ^{[1
,2
]}

Xiao, Wanyue ^{[1
,2
]}

Sun, Liguo ^{[3
]}

Shao, Jinjun ^{[1
,2
]}

Dong, Xiaochen ^{[1
,2
]}

机构：

[1] Nanjing Tech Univ NanjingTech, Key Lab Flexible Elect KLOFE, Nanjing 211800, Jiangsu, Peoples R China

[2] Nanjing Tech Univ NanjingTech, IAM, Nanjing 211800, Jiangsu, Peoples R China

[3] Binzhou Med Univ Hosp, Dept Radiol, Yantai 264100, Shangdong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 06期

关键词：

ORGANIC-DYE; TUMOR; NANOPARTICLES; AGENT; ABSORPTION; NANOSHEETS; RELEASE; MOS2;

D O I：

10.1039/c8cc07768a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A NIR photosensitizer pyrrolopyrrole aza-BODIPY (PPAB) was synthesized in a straightforward manner. Through the use of PPAB NPs as a photothermal agent, photoacoustic imaging (PAI) and NIR fluorescence imaging (NIR-FI) can be achieved in vivo. In addition, the photothermal ablation of tumor cells can be realized both in vitro and in vivo, even at a low concentration (0.5 mg kg(-1)).

引用

页码：790 / 793

页数：4

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