In the past 10 years our knowledge of hereditary breast cancer, and specifically the breast cancer susceptibility genes BRCA1 and BRCA2, has dramatically increased, as has our understanding of prevention options for high-risk women. Effective strategies to reduce the risk of breast cancer include prophylactic mastectomy, prophylactic oophorectomy, and chemoprevention. In this article we review the current evidence regarding the efficacy of each of these management strategies.
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Saitama Med Univ, Saitama Med Ctr, Dept Breast Care, Hidaka, Saitama, JapanSaitama Med Univ, Saitama Med Ctr, Dept Breast Care, Hidaka, Saitama, Japan
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IRCCS Osped Policlin San Martino, Unit Hereditary Canc, Genoa, ItalyIRCCS Osped Policlin San Martino, Unit Hereditary Canc, Genoa, Italy
Trevisan, Lucia
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Godino, Lea
Battistuzzi, Linda
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IRCCS Osped Policlin San Martino, Unit Hereditary Canc, Genoa, ItalyIRCCS Osped Policlin San Martino, Unit Hereditary Canc, Genoa, Italy
Battistuzzi, Linda
Innella, Giovanni
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Univ Bologna, Unit Med Genet, IRCCS Azienda Ospedaliero, Bologna, Italy
Univ Bologna, Dipartimento Sci Med & Chirurg, Bologna, ItalyIRCCS Osped Policlin San Martino, Unit Hereditary Canc, Genoa, Italy
Innella, Giovanni
Luppi, Elena
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Univ Bologna, Unit Med Genet, IRCCS Azienda Ospedaliero, Bologna, Italy
Univ Bologna, Dipartimento Sci Med & Chirurg, Bologna, ItalyIRCCS Osped Policlin San Martino, Unit Hereditary Canc, Genoa, Italy
Luppi, Elena
Buzzatti, Giulia
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IRCCS Osped Policlin San Martino, Unit Hereditary Canc, Genoa, ItalyIRCCS Osped Policlin San Martino, Unit Hereditary Canc, Genoa, Italy
Buzzatti, Giulia
Gismondi, Viviana
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IRCCS Osped Policlin San Martino, Unit Hereditary Canc, Genoa, ItalyIRCCS Osped Policlin San Martino, Unit Hereditary Canc, Genoa, Italy
Gismondi, Viviana
Blondeaux, Eva
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IRCCS Osped Policlin San Martino, UO Epidemiol Clin, Largo Rosanna Benzi 10, I-16132 Genoa, ItalyIRCCS Osped Policlin San Martino, Unit Hereditary Canc, Genoa, Italy
Blondeaux, Eva
Bonelli, Luigina Ada
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IRCCS Osped Policlin San Martino, UO Epidemiol Clin, Largo Rosanna Benzi 10, I-16132 Genoa, ItalyIRCCS Osped Policlin San Martino, Unit Hereditary Canc, Genoa, Italy
Bonelli, Luigina Ada
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Turchetti, Daniela
Varesco, Liliana
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IRCCS Osped Policlin San Martino, Unit Hereditary Canc, Genoa, ItalyIRCCS Osped Policlin San Martino, Unit Hereditary Canc, Genoa, Italy