Mycobacterium abscessus and β-Lactams: Emerging Insights and Potential Opportunities

被引：36
|
作者：
Story-Roller, Elizabeth [1 ]
Maggioncalda, Emily C. [1 ]
Cohen, Keira A. [2 ]
Lamichhane, Gyanu [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Div Infect Dis, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Div Pulm & Crit Care Med, Baltimore, MD USA
来源：
FRONTIERS IN MICROBIOLOGY | 2018年 / 9卷
关键词：
Mycobacterium abscessus; beta-lactams; peptidoglycan; LD-transpeptidase; beta-lactamase inhibitor; RAPIDLY GROWING MYCOBACTERIA; VITRO ANTIMICROBIAL SUSCEPTIBILITY; NONTUBERCULOUS MYCOBACTERIA; ANTIBIOTIC SUSCEPTIBILITY; SUBSP ABSCESSUS; CYSTIC-FIBROSIS; TUBERCULOSIS L; D-TRANSPEPTIDASE; NONCLASSICAL TRANSPEPTIDASE; CLINICAL-FEATURES; CRYSTAL-STRUCTURE;
D O I：
10.3389/fmicb.2018.02273
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
beta-lactams, the most widely used class of antibiotics, are well-tolerated, and their molecular mechanisms of action against many bacteria are well-documented. Mycobacterium abscessus (Mab) is a highly drug-resistant rapidly-growing nontuberculous mycobacteria (NTM). Only in recent years have we started to gain insight into the unique relationship between beta-lactams and their targets in Mab. In this mini-review, we summarize recent findings that have begun to unravel the molecular basis for overall efficacy of beta-lactams against Mab and discuss emerging evidence that indicates that we have yet to harness the full potential of this antibiotic class to treat Mab infections.
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页数：10
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