New cinnamylphenols from Dalbergia species with cancer chemopreventive activity

被引：20
|
作者：
Ito, C
Itoigawa, M [1 ]
Kanematsu, T
Ruangrungsi, N
Higashihara, H
Tokuda, H
Nishino, H
Furukawa, H
机构：
[1] Tokai Gakuen Univ, Miyoshi, Aichi 4700207, Japan
[2] Meijo Univ, Fac Pharm, Tempa Ku, Nagoya, Aichi 4688503, Japan
[3] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharmacognosy, Bangkok 10330, Thailand
[4] Kyoto Prefectural Univ Med, Dept Mol Biochem, Kamigyou Ku, Kyoto 6020841, Japan
来源：
JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 12期
关键词：
D O I：
10.1021/np0302450
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Five new cinnamylphenols (1,3-diphenylpropenes), dalberatins A (1), B (2), C (3), D (4), and E (5), were isolated from plants of the Dalbergia species. They were characterized and tested for their inhibitory activities against Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The cinnamylphenols were found to show remarkably potent activities. The result of the present investigation indicated that some of these cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters).
引用
收藏
页码：1574 / 1577
页数：4
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