Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans

被引：40
|
作者：
Marakalala, Mohlopheni J. [2 ]
Kerrigan, Ann M. [1 ]
Brown, Gordon D. [1 ]
机构：
[1] Univ Aberdeen, Inst Med Sci, Div Appl Med, Aberdeen Fungal Grp,Sect Immunol & Infect, Aberdeen AB25 2ZD, Scotland
[2] Univ Cape Town, Div Immunol, Inst Infect Dis & Mol Med, CLS, ZA-7925 Cape Town, South Africa
来源：
MAMMALIAN GENOME | 2011年 / 22卷 / 1-2期
基金：
新加坡国家研究基金会; 英国惠康基金;
关键词：
BETA-GLUCAN RECEPTOR; C-TYPE LECTIN; TOLL-LIKE RECEPTORS; CD8(+) T-CELLS; PATTERN-RECOGNITION RECEPTOR; CANDIDA-ALBICANS YEAST; INNATE IMMUNE-RESPONSE; VERSUS-HOST-DISEASE; DENDRITIC CELLS; FUNGAL-INFECTIONS;
D O I：
10.1007/s00335-010-9277-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease.
引用
收藏
页码：55 / 65
页数：11
相关论文
共 50 条
  • [1] Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans
    Mohlopheni J. Marakalala
    Ann M. Kerrigan
    Gordon D. Brown
    Mammalian Genome, 2011, 22 : 55 - 65
  • [2] The role of dectin-1 in antifungal immunity
    Herre, J
    Wiliment, JA
    Gordon, S
    Brown, GE
    CRITICAL REVIEWS IN IMMUNOLOGY, 2004, 24 (03) : 193 - 203
  • [3] Dectin-1 and its role in antifungal immunity
    Kimberg, Matti
    Brown, Gordon D.
    MEDICAL MYCOLOGY, 2008, 46 (07) : 631 - 636
  • [4] Toll-like receptors and Dectin-1 in antifungal defense
    Underhill, DM
    SHOCK, 2004, 21 : 9 - 9
  • [5] Role of dectin-1 in the host defense to infection with Cryptococcus neoformans
    Miyazato, Akiko
    Nakamura, Kiwamu
    Saijo, Shinobu
    Iwakura, Yoichiro
    Kaku, Mitsuo
    Kawakami, Kazuyoshi
    JOURNAL OF IMMUNOLOGY, 2007, 178
  • [6] PPARγ Controls Dectin-1 Expression Required for Host Antifungal Defense against Candida albicans
    Gales, Amandine
    Conduche, Annabelle
    Bernad, Jose
    Lefevre, Lise
    Olagnier, David
    Beraud, Maryse
    Martin-Blondel, Guillaume
    Linas, Marie-Denise
    Auwerx, Johan
    Coste, Agnes
    Pipy, Bernard
    PLOS PATHOGENS, 2010, 6 (01)
  • [7] The role of Dectin-1 in fungal asthma
    Lilly, Lauren
    Metz, Allison
    Dunaway, Chad
    Schwiebert, Lisa
    Steele, Chad
    JOURNAL OF IMMUNOLOGY, 2012, 188
  • [8] Dectin-1 is not required for the host defense to Cryptococcus neoformans
    Nakamura, Kiwamu
    Kinjo, Takeshi
    Saijo, Shinobu
    Miyazato, Akiko
    Adachi, Yoshiyuki
    Ohno, Naohito
    Fujita, Jiro
    Kaku, Mitsuo
    Iwakura, Ybichiro
    Kawakami, Kazuyoshi
    MICROBIOLOGY AND IMMUNOLOGY, 2007, 51 (11) : 1115 - 1119
  • [9] The role of dectin-1 in health and disease
    Kalia, Namarta
    Singh, Jatinder
    Kaur, Manpreet
    IMMUNOBIOLOGY, 2021, 226 (02)
  • [10] Genetic variants of dectin-1 and their antifungal immunity impact in hematologic malignancies: A comprehensive systematic review
    Aghaei, Mojtaba
    Khademi, Reyhane
    Far, Mohammad Ali Jalali
    Bahreiny, Seyed Sobhan
    Mahdizade, Amir Hossein
    Amirrajab, Nasrin
    CURRENT RESEARCH IN TRANSLATIONAL MEDICINE, 2024, 72 (04)
12345