Dectin-1 is not required for the host defense to Cryptococcus neoformans

被引：75

作者：

Nakamura, Kiwamu

Kinjo, Takeshi

Saijo, Shinobu

Miyazato, Akiko

Adachi, Yoshiyuki

Ohno, Naohito

Fujita, Jiro

Kaku, Mitsuo

Iwakura, Ybichiro

Kawakami, Kazuyoshi

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Infect Control, Lab Diagnost Internal Med, Sendai, Miyagi 9808575, Japan

[2] Univ Ryukyus, Fac Med, Dept Med Therapeut Control & Prevent Infect Dis, Okinawa 9030215, Japan

[3] Univ Tokyo, Inst Med Sci, Ctr Med Expt, Minato Ku, Tokyo 1088639, Japan

[4] Tohoku Univ Hosp, Infect Control Res Ctr, Sendai, Miyagi 9808575, Japan

[5] Tokyo Univ Pharm & Life Sci, Lab Immunopharmacol Microbial Prod, Hachioji, Tokyo 1920392, Japan

[6] CRESCENDO, Clin Evaluat Project, Sendai, Miyagi 9808575, Japan

[7] Tohoku Univ, Fac Med, Sch Hlth Sci, Dept Med Technol, Sendai, Miyagi 9808575, Japan

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2007年 / 51卷 / 11期

关键词：

Cryptococcus neoformans; dectin-1; host defense; dendritic cells; IL-12;

D O I：

10.1111/j.1348-0421.2007.tb04007.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dectin-1 is known as a sole receptor for P-glucan, a major cell wall component of fungal microorganisms. In the current study, we examined the role of this molecule in the host defense to Cryptococcus neoformans, an opportunistic fungal pathogen in AIDS patients. There was no significant difference in the clinical course and cytokine production between dectin-1 gene-deficient and control mice. These results indicate that dectin-1 is not likely essential for the development of host protective responses to C neoformans.

引用

页码：1115 / 1119

页数：5

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