From Host to Phage Metabolism: Hot Tales of Phage T4's Takeover of E. coli

被引:47
|
作者
Kutter, Elizabeth [1 ]
Bryan, Daniel [1 ]
Ray, Georgia [1 ]
Brewster, Erin [1 ]
Blasdel, Bob [1 ,2 ]
Guttman, Burton [1 ]
机构
[1] Evergreen State Coll, Bacteriophage Lab, Olympia, WA 98505 USA
[2] Katholieke Univ Leuven, Dept Biosyst, B-3000 Leuven, Belgium
来源
VIRUSES-BASEL | 2018年 / 10卷 / 07期
关键词
bacteriophage; Tevenvirinae; radiolabeling; genomic map; 2-D polyacrylamide gel electrophoresis; NEPHGE-SDS PAGE; ESCHERICHIA-COLI; PHOSPHOLIPID-SYNTHESIS; BACTERIOPHAGE T4D; MORPHOGENESIS; ACID; INFECTION; MUTANTS; GENOME; GENE;
D O I
10.3390/v10070387
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The mechanisms by which bacteriophage T4 converts the metabolism of its E. coli host to one dedicated to progeny phage production was the subject of decades of intense research in many labs from the 1950s through the 1980s. Presently, a wide range of phages are starting to be used therapeutically and in many other applications, and also the range of phage sequence data available is skyrocketing. It is thus important to re-explore the extensive available data about the intricacies of the T4 infection process as summarized here, expand it to looking much more broadly at other genera of phages, and explore phage infections using newly-available modern techniques and a range of appropriate environmental conditions.
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页数:17
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