Integrated Epigenetic and Transcriptional Single Cell Analysis of t(11;14) Myeloma and Its BCL2 Dependency

被引：0
|
作者：
Leblay, Noemie
Ahn, Sungwoo
Maity, Ranjan
Lee, Holly
Barakat, Ellie
Bahlis, Nizar J.
Neri, Paola
机构：
来源：
BLOOD | 2021年 / 138卷
关键词：
D O I：
10.1182/blood-2021-152993
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
725
引用
收藏
页数：3
相关论文
共 50 条
  • [21] THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors
    Cayrol, Florencia
    Praditsuktavorn, Pannee
    Fernando, Tharu M.
    Kwiatkowski, Nicholas
    Marullo, Rosella
    Calvo-Vidal, M. Nieves
    Phillip, Jude
    Pera, Benet
    Yang, Shao Ning
    Takpradit, Kaipol
    Roman, Lidia
    Gaudiano, Marcello
    Crescenzo, Ramona
    Ruan, Jia
    Inghirami, Giorgio
    Zhang, Tinghu
    Cremaschi, Graciela
    Gray, Nathanael S.
    Cerchietti, Leandro
    NATURE COMMUNICATIONS, 2017, 8
  • [22] THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors
    Florencia Cayrol
    Pannee Praditsuktavorn
    Tharu M. Fernando
    Nicholas Kwiatkowski
    Rosella Marullo
    M. Nieves Calvo-Vidal
    Jude Phillip
    Benet Pera
    Shao Ning Yang
    Kaipol Takpradit
    Lidia Roman
    Marcello Gaudiano
    Ramona Crescenzo
    Jia Ruan
    Giorgio Inghirami
    Tinghu Zhang
    Graciela Cremaschi
    Nathanael S. Gray
    Leandro Cerchietti
    Nature Communications, 8
  • [23] THE UTILITY OF BCL-1 PCT FOR DETECTION OF THE T(11-14) IN MANTLE CELL LYMPHOMA - AN ANALYSIS OF 25 CASES
    GASCOYNE, RD
    ADOMAT, SA
    HORSMAN, DE
    LABORATORY INVESTIGATION, 1995, 72 (01) : A110 - A110
  • [24] Significance of CMYC, t(14;18), BCL2 Protein Expression, and Ki-67 Index in Diffuse Large B-Cell Lymphoma
    Egan, Jennifer A.
    Hunt, Kristin E.
    Reichard, Kaari K.
    Chiu, WingKeung M.
    Dunphy, Cherie H.
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2009, 132 (04) : 640 - 640
  • [25] Diffuse large B cell lymphomas with a t(14;18) have an inferior outcome compared to bcl2 positive cases lacking the translocation.
    Barrans, SL
    O'Connor, SJM
    Owen, R
    Haynes, AP
    Morgan, GJ
    Jack, AS
    BLOOD, 2001, 98 (11) : 329A - 330A
  • [26] The Bcl-2 specific BH3 mimetic ABT-199: a promising targeted therapy for t(11;14) multiple myeloma
    Touzeau, C.
    Dousset, C.
    Le Gouill, S.
    Sampath, D.
    Leverson, J. D.
    Souers, A. J.
    Maiga, S.
    Bene, M. C.
    Moreau, P.
    Pellat-Deceunynck, C.
    Amiot, M.
    LEUKEMIA, 2014, 28 (01) : 210 - 212
  • [27] The Bcl-2 specific BH3 mimetic ABT-199: a promising targeted therapy for t(11;14) multiple myeloma
    C Touzeau
    C Dousset
    S Le Gouill
    D Sampath
    J D Leverson
    A J Souers
    S Maïga
    M C Béné
    P Moreau
    C Pellat-Deceunynck
    M Amiot
    Leukemia, 2014, 28 : 210 - 212
  • [28] Three years follow-up of Venetoclax in advanced-stage, relapsed or refractory AL amyloidosis with cardiac involvement and t(11;14) with BCL2 expression
    Rieger, Max J.
    Pabst, Thomas
    Jeker, Barbara
    Paul, Pamella
    Bergamini, Fabio
    Buehler, Marco M.
    Condoluci, Adalgisa
    Flammer, Andreas J.
    Rossi, Davide
    Stussi, Georg
    Gerber, Bernhard
    Schwotzer, Rahel
    ANNALS OF HEMATOLOGY, 2024, 103 (10) : 4163 - 4170
  • [29] Integrated temporal transcriptional and epigenetic single-cell analysis reveals the intrarenal immune characteristics in an early-stage model of IgA nephropathy during its acute injury
    Xu, Chen
    Zhang, Yiwei
    Zhou, Jian
    Zhang, Jiangnan
    Dong, Hui
    Chen, Xiangmei
    Tian, Yi
    Wu, Yuzhang
    FRONTIERS IN IMMUNOLOGY, 2024, 15
  • [30] Correction: Corrigendum: THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors
    Florencia Cayrol
    Pannee Praditsuktavorn
    Tharu M. Fernando
    Nicholas Kwiatkowski
    Rossella Marullo
    M. Nieves Calvo-Vidal
    Jude Phillip
    Benet Pera
    Shao Ning Yang
    Kaipol Takpradit
    Lidia Roman
    Marcello Gaudiano
    Ramona Crescenzo
    Jia Ruan
    Giorgio Inghirami
    Tinghu Zhang
    Graciela Cremaschi
    Nathanael S Gray
    Leandro Cerchietti
    Nature Communications, 8
12345