Death by deamination: A novel host restriction system for HIV-1

被引：55
|
作者：
Goff, SP [1 ]
机构：
[1] Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New York, NY 10032 USA
来源：
CELL | 2003年 / 114卷 / 03期
关键词：
D O I：
10.1016/S0092-8674(03)00602-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A human gene with potent antiretroviral activity has recently been found to encode a new member of the family of cytidine deaminases, previously known to be involved in mRNA editing, immunoglobulin gene class switching, and immunoglobulin gene hypermutation. The enzyme attacks viral DNA as it is synthesized in infected cells and prevents the formation of functional proviruses. The Vif gene of HIV-1 blocks this host restriction and so allows virus replication.
引用
收藏
页码：281 / 283
页数：3
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