RETRACTED: Long non-coding RNA PCAT-1 promotes cardiac fibroblast proliferation via upregulating TGF-β1 (Retracted Article)

被引：2
|
作者：
Chen, Q. [1 ]
Feng, C. [2 ]
Liu, Y. [3 ]
Li, Q-F [1 ]
Qiu, F-Y [1 ]
Wang, M-H [1 ]
Shen, Z-D
Fu, G-S [1 ]
机构：
[1] Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Biomed Res Ctr,Dept Cardiol, Hangzhou, Zhejiang, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Dept Cardiol, Shanghai, Peoples R China
[3] Nanjing Univ, Med Sch, Affiliated Nanjing Drum Tower Hosp, Dept Cardiol, Nanjing, Jiangsu, Peoples R China
来源：
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2019年 / 23卷 / 23期
基金：
中国国家自然科学基金;
关键词：
Long non-coding RNA; Atrial fibrillation; PCAT-1; TGF-beta; 1; ATRIAL-FIBRILLATION PATIENTS; CELL-PROLIFERATION; LNCRNA PCAT1; IDENTIFICATION; EXPRESSION; NEAT1;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
OBJECTIVE: Recently, the vital functions of long non-coding RNAs (lncRNAs) in many diseases have been explored. This study aims to identify the function of lncRNA PCAT-1 in the development of atrial fibrillation (AF). PATIENTS AND METHODS: Real Time-quantitative Polymerise Chain Reaction (RT-qPCR) was performed to detect PCAT-1 expression in right atrial appendage (RAA) tissues of 51 AF patients and 35 patients with sinus rhythm (SR). Besides. cell proliferation assay was conducted in AC16 cells with PCAT-1 knockdown. Molecular mechanism of PCAT-1 in influencing the progression of AF was finally investigated. RESULTS: PCAT-1 expression was higher in RAA tissues of AF patients than those of SR patients. Moreover, knockdown of PCAT-1 inhibited proliferation in AC16 cells. Transforming growth factor-beta 1 (TGF-beta 1) was a target of PCAT-1 and its expression in AF tissues positively correlated to PCAT-1 expression. CONCLUSIONS: PCAT-1 could promote cell proliferation of AF via promoting TGF-beta 1, which may provide a new theory for AF development.
引用
收藏
页码：10517 / 10522
页数：6
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