New vobasinyl-ibogan type bisindole alkaloids from Tabernaemontana corymbosa

被引：19
|
作者：
Zhang, Yu [1 ]
Guo, Lingli [1 ]
Yang, Guangmei [1 ]
Guo, Feng [1 ]
Di, Yingtong [1 ]
Li, Shunlin [1 ]
Chen, Duozhi [1 ]
Hao, Xiaojiang [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
来源：
FITOTERAPIA | 2015年 / 100卷
基金：
中国国家自然科学基金;
关键词：
Tabernaemontana corymbosa; Bisindole alkaloids; Tabercorines A-C; Cytotoxicity; INDOLE ALKALOIDS;
D O I：
10.1016/j.fitote.2014.11.016
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Ten vobasinyl-ibogan type bisindole alkaloids, including three new ones, tabercorines A-C (1-3), and a new natural product, 17-acetyl-tabemaecorymbosine A (4), were isolated from the twigs and leaves of Tabernaemontana coymbosa. Their structures were elucidated on the basis of spectroscopic data, and the NMR data of 17-acetyl-tabemaecorymbosine A (4) was assigned and reported for the first time. The absolute configurations of 1-4 were determined by CD exciton chirality method. All new compounds were evaluated for in vitro cytotoxicity against various human cancer cell lines. Compounds 1 and 4 showed significant inhibitory effects with IC50 values comparable to those of cisplatin. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：150 / 155
页数：6
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