THE EVOLVING ROLE OF RADIATION THERAPY IN THE MANAGEMENT OF MALIGNANT MELANOMA

被引:53
|
作者
Khan, Niloufer [1 ]
Khan, Mohammad K. [2 ,3 ]
Almasan, Alex [2 ,3 ]
Singh, Arun D. [2 ,3 ]
Macklis, Roger [2 ,3 ]
机构
[1] Case Western Reserve Univ, Sch Med, Cleveland, OH USA
[2] Cleveland Clin, Taussig Canc Inst, Lerner Coll Med, Cleveland, OH 44106 USA
[3] Cleveland Clin, Cole Eye Inst, Cleveland, OH 44106 USA
基金
美国国家卫生研究院;
关键词
Hypofractionation; Brachytherapy; Melanoma cell cycle; Radiosurgery; Biological agents; COMS RANDOMIZED-TRIAL; COLLABORATIVE OCULAR MELANOMA; GAMMA-KNIFE RADIOSURGERY; LARGE CHOROIDAL MELANOMA; METASTATIC MELANOMA; BRAIN METASTASES; CUTANEOUS MELANOMA; HIGH-RISK; POSTOPERATIVE RADIOTHERAPY; PREENUCLEATION RADIATION;
D O I
10.1016/j.ijrobp.2010.12.071
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The incidence of melanoma is rising in the United States, leading to an estimated 68,720 new diagnoses and 8,650 deaths annually. The natural history involves metastases to lymph nodes, lung, liver, brain, and often to other sites. Primary treatment for melanoma is surgical excision of the primary tumor and affected lymph nodes. The role of adjuvant or definitive radiation therapy in the treatment of melanoma remains controversial, because melanoma has traditionally been viewed as a prototypical radioresistant cancer. However, recent studies suggest that under certain clinical circumstances, there may be a significant role for radiation therapy in melanoma treatment. Stereotactic radiosurgery for brain metastases has shown effective local control. High dose per fraction radiation therapy has been associated with a lower rate of locoregional recurrence of sinonasal melanoma. Plaque brachytherapy has evolved into a promising alternative to enucleation at the expense of moderate reduction in visual acuity. Adjuvant radiation therapy following lymphadenectomy in node-positive melanoma prevents local and regional recurrence. The newer clinical data along with emerging radiobiological data indicate that radiotherapy is likely to play a greater role in melanoma management and should be considered as a treatment option. (C) 2011 Elsevier Inc.
引用
收藏
页码:645 / 654
页数:10
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