Synthesis, X-ray structure of organometallic ruthenium (II) p-cymene complexes based on P- and N- donor ligands and their in vitro antibacterial and anticancer studies

被引：18
|
作者：
Chuklin, Parichad [1 ,2 ]
Chalermpanaphan, Vachirawit [1 ,2 ]
Nhukeaw, Tidarat [3 ]
Saithong, Saowanit [1 ,2 ]
Chainok, Kittipong [4 ]
Phongpaichit, Sauwalak [5 ,6 ]
Ratanaphan, Adisorn [3 ]
Leesakul, Nararak [1 ,2 ]
机构：
[1] Prince Songkla Univ, Fac Sci, Dept Chem, Hat Yai 90110, Songkhla, Thailand
[2] Prince Songkla Univ, Fac Sci, Ctr Innovat Chem, Hat Yai 90110, Songkhla, Thailand
[3] Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmaceut Chem, Hat Yai 90112, Songkhla, Thailand
[4] Thammasat Univ, Fac Sci & Technol, Dept Phys, Klongluang 12120, Pathumthani, Thailand
[5] Prince Songkla Univ, Fac Sci, Nat Prod Res Ctr, Hat Yai 90110, Songkhla, Thailand
[6] Prince Songkla Univ, Fac Sci, Dept Microbiol, Hat Yai 90110, Songkhla, Thailand
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2017年 / 846卷
关键词：
Antimicrobial activity; Anticancer activity; Ru(II)-Arene; ANTITUMOR-ACTIVITY; SPECTRA; IR(III); RH(III); RU(II);
D O I：
10.1016/j.jorganchem.2017.06.017
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Two new arene compounds containing bis-diphosphinomethane (dppm) and tert-butylpyridine (tbp) ligands as important components in ruthenium(II) complexes were synthesized and characterized by Xray crystallography, and spectroscopy of H-1 NMR, C-13 NMR, 2D-NMR, FTIR and CHN analysis. The synthesized complexes were evaluated in vitro as anticancer agents of human breast cancer cell lines, MCF-7 and HCC1937, using the MTT assay. Both complexes showed an interesting behavior especially the compound of [Ru(p-cymene) (dppm) Cl-2]. It exhibited anticancer activity against both tested cell lines with greater IC50 values than cisplatin against all breast cancer cells. Both MCF-7 and HCC1937 cells exhibited 16-fold sensitivity to the [Ru(p-cymene)(dppm) Cl-2] compared to cisplatin. Furthermore, the [Ru(p-cymene)(dppm) Cl-2] complex significantly inhibited both Staphylococcus aureus ATCC25923 and MRSA = methicillin resistant Staphylococcus aureus with MIC/MBC values of 8/200 mg mL(-1) and 32/128 mg mL(-1), respectively. In addition, it showed inhibition activity on Cryptococcus neoformans ATCC90113 flucytosine -resistant, CN90113, with an MIC/MBC value of 64/128 mg mL(-1). (C) 2017 Elsevier B.V. All rights reserved.
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收藏
页码：242 / 250
页数：9
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