Phosphine-catalyzed [3+2] annulation of β-sulfonamido-substituted enones with trans-α-cyano-α,β-unsaturated ketones for the synthesis of highly substituted pyrrolidines

被引：4

作者：

Gao, Zhenzhen ^{[1
]}

Xie, Lei ^{[1
]}

Ji, Lusha ^{[1
]}

Ma, Xin ^{[1
]}

Li, Xiaojing ^{[1
]}

Liu, Honglei ^{[2
]}

Guo, Hongchao ^{[3
]}

机构：

[1] Liaocheng Univ, Sch Pharm, Liaocheng 252000, Shandong, Peoples R China

[2] Qingdao Univ, Coll Mat Sci & Engn, Qingdao 266071, Shandong, Peoples R China

[3] China Agr Univ, Dept Appl Chem, Beijing 100193, Peoples R China

来源：

RSC ADVANCES | 2021年 / 11卷 / 63期

关键词：

ORGANOCATALYTIC ASYMMETRIC-SYNTHESIS; BAYLIS-HILLMAN CARBONATES; FACILE SYNTHESIS; IMINES; CYCLOADDITION; 3-PYRROLINES; ALLENES;

D O I：

10.1039/d1ra07881j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To synthesize highly substituted pyrrolidines, we developed a phosphine-catalyzed [3 + 2] annulation of beta-sulfonamido-substituted enones with trans-alpha-cyano-alpha,beta-unsaturated ketones. We prepared a series of pyrrolidines under mild conditions with high yields and moderate-to-good diastereoselectivities. A catalytic mechanism for this reaction is suggested.

引用

页码：40136 / 40139

页数：4

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