Discovery of BMS-986160 as a second-generation inhibitor of the hepatitis C virus NS3/4A with pan-genotypic antiviral activity

被引：0

作者：

Sun, Li-Qiang ^{[1
]}

Mull, Eric ^{[3
]}

Kandhasamy, Sarkunam ^{[2
]}

Baratam, Venkata Rao ^{[2
]}

Puttaswamy, Sunitha ^{[2
]}

Pulicharla, Nagalakshmi ^{[2
]}

Vishwakrishnan, Sureshbabu ^{[2
]}

Reddy, Subba ^{[2
]}

Trivedi, Ravi ^{[2
]}

Sinha, Sarmistha ^{[2
]}

Sivaprasad, Sankar ^{[2
]}

Rao, Abhijith ^{[2
]}

Desai, Salil ^{[2
]}

Ghosh, Kaushik ^{[2
]}

Rajamani, Ramkumar ^{[1
]}

Wang, Ying-Kai ^{[3
]}

Fang, Hua ^{[3
]}

Mathur, Arvind ^{[1
]}

Rampulla, Richard ^{[1
]}

Jenkins, Susan ^{[3
]}

Meanwell, Nicholas ^{[1
]}

McPhee, Fiona ^{[3
]}

Scola, Paul ^{[3
]}

机构：

[1] Bristol Myers Squibb Res & Dev, Princeton, NJ USA

[2] Biocon Bristol Myers Squibb R&D Ctr, Bangalore, Karnataka, India

[3] Bristol Myers Squibb Res & Dev, Wallingford, CT USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 258卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

42-MEDI

引用

页数：1

共 50 条

[31] Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor
Neelamkavil, Santhosh F.
Agrawal, Sony
Bara, Thomas
Bennett, Chad
Bhat, Sathesh
Biswas, Dipshikha
Brockunier, Linda
Buist, Nicole
Burnette, Duane
Cartwright, Mark
Chackalamannil, Samuel
Chase, Robert
Chelliah, Mariappan
Chen, Austin
Clasby, Martin
Colandrea, Vincent J.
Davies, Ian W.
Eagen, Keith
Guo, Zhuyan
Han, Yongxin
Howe, John
Jayne, Charles
Josien, Hubert
Kargman, Stacia
Marcantonio, Karen
Miao, Shouwu
Miller, Randy
Nolting, Andrew
Pinto, Patrick
Rajagopalan, Murali
Ruck, Rebecca T.
Shah, Unmesh
Soriano, Aileen
Sperbeck, Donald
Velazquez, Francisco
Wu, Jin
Xia, Yan
Venkatraman, Srikanth
ACS MEDICINAL CHEMISTRY LETTERS, 2016, 7 (01): : 111 - 116
[32] Telaprevir: An NS3/4A Protease Inhibitor for the Treatment of Chronic Hepatitis C
Smith, Lisa S.
Nelson, Michael
Naik, Sagar
Woten, Joanna
ANNALS OF PHARMACOTHERAPY, 2011, 45 (05) : 639 - 648
[33] VANIPREVIR HCV NS3/4A Protease Inhibitor Treatment of Hepatitis C
Hammond, E.
Lucas, A.
Lucas, M.
Phillips, E.
Gaudieri, S.
DRUGS OF THE FUTURE, 2010, 35 (10) : 803 - 813
[34] Furaprevir HCV NS3/4A protease inhibitor Treatment of chronic hepatitis C virus infection
Ghosh, Prithwish
Nehra, Vandana
Temesgen, Zelalem
DRUGS OF THE FUTURE, 2022, 47 (08) : 557 - 565
[35] MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease
Liverton, Nigel J.
Carroll, Steven S.
DiMuzio, Jillian
Fandozzi, Christine
Graham, Donald J.
Hazuda, Daria
Holloway, M. Katherine
Ludmerer, Steven W.
McCauley, John A.
McIntyre, Charles J.
Olsen, David B.
Rudd, Michael T.
Stahlhut, Mark
Vacca, Joseph P.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (01) : 305 - 311
[36] Discovery of GS-9256: A novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity
Sheng, X. Christopher
Casarez, Anthony
Cai, Ruby
Clarke, Michael O.
Chen, Xiaowu
Cho, Aesop
Delaney, William E.
Doerffler, Edward
Ji, Mingzhe
Mertzman, Michael
Pakdaman, Rowchanak
Pyun, Hyung-Jung
Rowe, Tanisha
Wu, Qiaoyin
Xu, Jie
Kim, Choung U.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (03) : 1394 - 1396
[37] Functional and therapeutic analysis of hepatitis C virus NS3•4A protease control of antiviral immune defense
Johnson, Cynthia L.
Owen, David M.
Gale, Michael, Jr.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (14) : 10792 - 10803
[38] An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
Daniel Lamarre
Paul C. Anderson
Murray Bailey
Pierre Beaulieu
Gordon Bolger
Pierre Bonneau
Michael Bös
Dale R. Cameron
Mireille Cartier
Michael G. Cordingley
Anne-Marie Faucher
Nathalie Goudreau
Stephen H. Kawai
George Kukolj
Lisette Lagacé
Steven R. LaPlante
Hans Narjes
Marc-André Poupart
Jean Rancourt
Roel E. Sentjens
Roger St George
Bruno Simoneau
Gerhard Steinmann
Diane Thibeault
Youla S. Tsantrizos
Steven M. Weldon
Chan-Loi Yong
Montse Llinàs-Brunet
Nature, 2003, 426 : 186 - 189
[39] An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
Lamarre, D
Anderson, PC
Bailey, M
Beaulieu, P
Bolger, G
Bonneau, P
Bös, M
Cameron, DR
Cartier, M
Cordingley, MG
Faucher, AM
Goudreau, N
Kawai, SH
Kukolj, G
Lagacé, L
LaPlante, SR
Narjes, H
Poupart, MA
Rancourt, J
Sentjens, RE
St George, R
Simoneau, B
Steinmann, G
Thibeault, D
Tsantrizos, YS
Weldon, SM
Yong, CL
Llinàs-Brunet, M
NATURE, 2003, 426 (6963) : 186 - 189
[40] NS3•4A protease as a target for interfering with hepatitis C virus replication
Perni, RB
DRUG NEWS & PERSPECTIVES, 2000, 13 (02) : 69 - 77

← 1 2 3 4 5 →