Enantiomeric separation of optically active pyridazinone derivatives by chiral HPLC

被引：5

作者：

Bidló-Iglóy, M ^{[1
]}

Mátyus, P ^{[1
]}

机构：

[1] Inst Drug Res, H-1325 Budapest, Hungary

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1999年 / 19卷 / 3-4期

关键词：

pyridazinone derivatives; Chiralcel columns; chiral HPLC;

D O I：

10.1016/S0731-7085(98)00243-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Several 4,5-disubstituted 3(2H)-pyridazinone derivatives containing 2-hydroxymethylpyrrolidino moiety as a chiral building block were synthetized. Separation of enantiomers was carried out by chiral HPLC on Chiralcel OJ and OF columns. Mobile phases consisted of hexane, ethanol and 2-propanol. Chiralcel OJ column was capable of separating most of the enantiomeric pairs. For one type of compound, Chiralcel OF column was used for separation. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：487 / 490

页数：4

共 50 条

[31] Recent Advances in SPE-Chiral-HPLC Methods for Enantiomeric Separation of Chiral Drugs in Biological Samples
Ali, Imran
Alam, Syed Dilshad
Al-Othman, Zeid A.
Farooqi, Javed A.
JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2013, 51 (07) : 645 - 654
[32] Chiral Recognition Ability of an Optically Active Poly(diphenylacetylene) as a Chiral Stationary Phase for HPLC
Maeda, Katsuhiro
Maruta, Miyuki
Shimomura, Kouhei
Ikai, Tomoyuki
Kanoh, Shigeyoshi
CHEMISTRY LETTERS, 2016, 45 (09) : 1063 - 1065
[33] Direct enantiomeric separation and determination of enantiomeric purity of methoxytetrahydro-naphthalene derivatives and melatonin ligands by HPLC using RSP-β-cyclodextrin as chiral stationary phase
Lipka, E.
Bonte, J. -P.
Vaccher, C.
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2006, 29 (09) : 1235 - 1245
[34] Analytical and Preparative Chiral Separation of β-Carboline Derivatives, LDL Oxidation Inhibitors, Using HPLC and CE Methodologies: Determination of Enantiomeric Purity
Lipka, Emmanuelle
Yous, Said
Furman, Christophe
Carato, Pascal
Deghaye, Carole
Bonte, Jean-Paul
Vaccher, Claude
CHROMATOGRAPHIA, 2012, 75 (7-8) : 337 - 345
[35] Analytical and Preparative Chiral Separation of β-Carboline Derivatives, LDL Oxidation Inhibitors, Using HPLC and CE Methodologies: Determination of Enantiomeric Purity
Emmanuelle Lipka
Saïd Yous
Christophe Furman
Pascal Carato
Carole Deghaye
Jean-Paul Bonte
Claude Vaccher
Chromatographia, 2012, 75 : 337 - 345
[36] Optically active distorted cyclic triptycenes: chiral stationary phases for HPLC
Ikai, Tomoyuki
Nagata, Naoya
Awata, Seiya
Wada, Yuya
Maeda, Katsuhiro
Mizuno, Motohiro
Swager, Timothy M.
RSC ADVANCES, 2018, 8 (37): : 20483 - 20487
[37] A validated chiral HPLC method for the enantiomeric separation of Linezolid on amylose based stationary phase
Narayana, CL
Suresh, T
Rao, SM
Dubey, PK
Babu, JM
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2003, 32 (01) : 21 - 28
[38] Recent developments in the HPLC enantiomeric separation using chiral selectors identified by a combinatorial strategy
Ravelet, Corinne
Peyrin, Eric
JOURNAL OF SEPARATION SCIENCE, 2006, 29 (10) : 1322 - 1331
[39] Enantiomeric separation of fused polycycles by HPLC with cyclodextrin and macrocyclic glycopeptide chiral stationary phases
Han, XX
Huang, QH
Ding, J
Larock, RC
Armstrong, DW
SEPARATION SCIENCE AND TECHNOLOGY, 2005, 40 (13) : 2745 - 2759
[40] Enantiomeric separation of cyclopropane derivatives on a polysaccharide-based chiral stationary phase
Ghanem, A
Hoenen, H
Müller, P
Aboul-Enein, HY
ANALYTICA CHIMICA ACTA, 2005, 538 (1-2) : 15 - 24

← 1 2 3 4 5 →