Expression of GSK3B in peripheral blood of patients with Parkinson's disease

被引：1
|
作者：
Filatova, E. V. [1 ]
Shadrina, M. I. [1 ]
Karabanov, A. V. [2 ]
Slominsky, P. A. [1 ]
Illarioshkin, S. N. [2 ]
Ivanova-Smolenskaya, I. A. [2 ]
Limborska, S. A. [1 ]
机构：
[1] Russian Acad Sci, Inst Mol Genet, Moscow 123182, Russia
[2] Russian Acad Med Sci, Ctr Neurol Sci, Moscow 125367, Russia
来源：
MOLECULAR BIOLOGY | 2011年 / 45卷 / 03期
基金：
俄罗斯基础研究基金会;
关键词：
expression level; GSK3B; Parkinson's disease; real-time polymerase chain reaction; TAU-PROTEIN; DOPAMINE; BRAIN; GLYCOGEN-SYNTHASE-KINASE-3; LYMPHOCYTES; GENE;
D O I：
10.1134/S0026893311020063
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Parkinson's disease (PD) is the second most common progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons. Detecting changes in gene expression in untreated de novo patients with PD is important for understanding the disease pathogenesis and for identifying biomarkers of the preclinical stage of PD. In this study, the expression of the glycogen synthase kinase-3 beta gene (GSK3B) was investigated in the peripheral blood of several groups of neurological patients using reverse transcription reaction and real-time PCR. Our results suggest that the GSK3B expression level cannot serve as a biomarker for early stages of PD.
引用
收藏
页码：417 / 420
页数：4
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