Expression of GSK3B in peripheral blood of patients with Parkinson's disease

被引：1
|
作者：
Filatova, E. V. [1 ]
Shadrina, M. I. [1 ]
Karabanov, A. V. [2 ]
Slominsky, P. A. [1 ]
Illarioshkin, S. N. [2 ]
Ivanova-Smolenskaya, I. A. [2 ]
Limborska, S. A. [1 ]
机构：
[1] Russian Acad Sci, Inst Mol Genet, Moscow 123182, Russia
[2] Russian Acad Med Sci, Ctr Neurol Sci, Moscow 125367, Russia
来源：
MOLECULAR BIOLOGY | 2011年 / 45卷 / 03期
基金：
俄罗斯基础研究基金会;
关键词：
expression level; GSK3B; Parkinson's disease; real-time polymerase chain reaction; TAU-PROTEIN; DOPAMINE; BRAIN; GLYCOGEN-SYNTHASE-KINASE-3; LYMPHOCYTES; GENE;
D O I：
10.1134/S0026893311020063
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Parkinson's disease (PD) is the second most common progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons. Detecting changes in gene expression in untreated de novo patients with PD is important for understanding the disease pathogenesis and for identifying biomarkers of the preclinical stage of PD. In this study, the expression of the glycogen synthase kinase-3 beta gene (GSK3B) was investigated in the peripheral blood of several groups of neurological patients using reverse transcription reaction and real-time PCR. Our results suggest that the GSK3B expression level cannot serve as a biomarker for early stages of PD.
引用
收藏
页码：417 / 420
页数：4
相关论文
共 50 条
  • [1] Expression of GSK3B in peripheral blood of patients with Parkinson’s disease
    E. V. Filatova
    M. I. Shadrina
    A. V. Karabanov
    P. A. Slominsky
    S. N. Illarioshkin
    I. A. Ivanova-Smolenskaya
    S. A. Limborska
    Molecular Biology, 2011, 45
  • [2] GSK3B polymorphisms alter transcription and splicing in Parkinson's disease
    Kwok, JBJ
    Hallupp, M
    Loy, CT
    Chan, DKY
    Woo, J
    Mellick, GD
    Buchanan, DD
    Silburn, PA
    Halliday, GM
    Schofield, PR
    ANNALS OF NEUROLOGY, 2005, 58 (06) : 829 - 839
  • [3] SNCA, MAPT, and GSK3B in Parkinson disease: a gene-gene interaction study
    Wider, C.
    Vilarino-Gueell, C.
    Heckman, M. G.
    Jasinska-Myga, B.
    Ortolaza-Soto, A. I.
    Diehl, N. N.
    Crook, J. E.
    Cobb, S. A.
    Bacon, J. A.
    Aasly, J. O.
    Gibson, J. M.
    Lynch, T.
    Uitti, R. J.
    Wszolek, Z. K.
    Farrer, M. J.
    Ross, O. A.
    EUROPEAN JOURNAL OF NEUROLOGY, 2011, 18 (06) : 876 - 881
  • [4] Increased platelet GSK3B activity in patients with mild cognitive impairment and Alzheimer's disease
    Forlenza, Orestes V.
    Torres, Carolina A.
    Talib, Leda L.
    de Paula, Vanessa J.
    Joaquim, Helena P. G.
    Diniz, Breno S.
    Gattaz, Wagner F.
    JOURNAL OF PSYCHIATRIC RESEARCH, 2011, 45 (02) : 220 - 224
  • [5] Association of GSK3B with Alzheimer disease and frontotemporal dementia
    Schaffer, Barbara A. J.
    Bertram, Lars
    Miller, Bruce L.
    Mullin, Kristina
    Weintraub, Sandra
    Johnson, Nancy
    Bigio, Eileen H.
    Mesulam, Marsel
    Wiedau-Pazos, Martina
    Jackson, George R.
    Cummings, Jeffrey L.
    Cantor, Rita M.
    Levey, Allan I.
    Tanzi, Rudolph E.
    Geschwind, Daniel H.
    ARCHIVES OF NEUROLOGY, 2008, 65 (10) : 1368 - 1374
  • [6] MAPT rs242562 and GSK3B rs334558 are associated with Parkinson’s Disease in central China
    Lan Yu
    Jinsha Huang
    Desheng Zhai
    Ling Liu
    Kexin Guo
    Xi Long
    Jing Xiong
    Zhentao Zhang
    Youpei Wang
    Ying Zhao
    Ping Wu
    Dingan Wang
    Zhicheng Lin
    Jing Wu
    Nian Xiong
    Tao Wang
    BMC Neuroscience, 15
  • [7] MAPT rs242562 and GSK3B rs334558 are associated with Parkinson's Disease in central China
    Yu, Lan
    Huang, Jinsha
    Zhai, Desheng
    Liu, Ling
    Guo, Kexin
    Long, Xi
    Xiong, Jing
    Zhang, Zhentao
    Wang, Youpei
    Zhao, Ying
    Wu, Ping
    Wang, Dingan
    Lin, Zhicheng
    Wu, Jing
    Xiong, Nian
    Wang, Tao
    BMC NEUROSCIENCE, 2014, 15
  • [8] NEUROPROTECTION TARGETING AT GSK3B
    Chen, G.
    Ke, Z. J.
    Luo, J.
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2011, 35 (06) : 281A - 281A
  • [9] Expression proteomics of peripheral blood lymphocytes from Parkinson's disease patients
    Mila, S.
    Albo, A. Giuliano
    Corpillo, D.
    Zibetti, M.
    Bergamasco, B.
    Lopiano, L.
    Fasano, M.
    MOVEMENT DISORDERS, 2006, 21 : S583 - S584
  • [10] Genetic Variants of GSK3B are Associated with Biomarkers for Alzheimer's Disease and Cognitive Function
    Kettunen, Petronella
    Larsson, Susanna
    Holmgren, Sandra
    Olsson, Sandra
    Minthon, Lennart
    Zetterberg, Henrik
    Blennow, Kaj
    Nilsson, Staffan
    Sjolander, Annica
    JOURNAL OF ALZHEIMERS DISEASE, 2015, 44 (04) : 1313 - 1322
12345