The long reach of noncoding RNAs

被引：17

作者：

Sotillo, Elena ^{[1
,2
]}

Thomas-Tikhonenko, Andrei ^{[1
,2
]}

机构：

[1] Childrens Hosp Philadelphia, Div Canc Pathobiol, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Philadelphia, PA 19104 USA

来源：

NATURE GENETICS | 2011年 / 43卷 / 07期

基金：

美国国家卫生研究院;

关键词：

TRANSCRIPTIONAL RESPONSE; H19; GENE; NF-Y; P53; REPRESSION; PROMOTERS;

D O I：

10.1038/ng.870

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Transcription of genomic loci containing protein-coding genes often yields not only cognate mRNAs but also assorted noncoding RNAs (ncRNAs), which typically map in the vicinity of transcription start sites. A new study shows that far from being random byproducts of gene expression, many long ncRNAs (lncRNAs) are synthesized in a coordinate fashion and control important cellular processes, such as survival in the face of DNA damage.

引用

页码：616 / 617

页数：2

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